CAJ | 학술논문

目的：探讨危重症患者胰岛素敏感性变化及其与白细胞介素-6(IL-6)、C反应蛋白(CRP)的相关性。方法101例危重症患者,按入院后血糖水平分为危重非高血糖组(50例)及危重并高血糖组(51例),分别测定空腹血糖(FBG)、空腹胰岛素(FINS)、IL-6、CRP等,计算胰岛素敏感性指数(ISI),并与52例健康人(健康组)进行比较。结果健康组、危重非高血糖组患者、危重并高血糖组患者相比FBG、IL-6、CRP依次升高(F=124.402、184.523、695.431, P<0.01), FINS、ISI逐渐下降(F=12.795、42.32, P<0.01), ISI与IL-6、CRP呈负相关(r=-0.424、-0.532, P<0.01)。结论危重应激高血糖与胰岛素敏感性下降有关,炎症反应是危重症患者胰岛素敏感性下降的原因之一。
목적：탐토위중증환자이도소민감성변화급기여백세포개소-6(IL-6)、C반응단백(CRP)적상관성。방법101례위중증환자,안입원후혈당수평분위위중비고혈당조(50례)급위중병고혈당조(51례),분별측정공복혈당(FBG)、공복이도소(FINS)、IL-6、CRP등,계산이도소민감성지수(ISI),병여52례건강인(건강조)진행비교。결과건강조、위중비고혈당조환자、위중병고혈당조환자상비FBG、IL-6、CRP의차승고(F=124.402、184.523、695.431, P<0.01), FINS、ISI축점하강(F=12.795、42.32, P<0.01), ISI여IL-6、CRP정부상관(r=-0.424、-0.532, P<0.01)。결론위중응격고혈당여이도소민감성하강유관,염증반응시위중증환자이도소민감성하강적원인지일。
Objective To investigate the change of insulin sensitivity in patients with critical disease and its correlation with interleukin-6 (IL-6) and C-reactive protein (CRP). Methods A total of 101 patients with critical disease were divided into critical non-hyperglycemia group (n=50) and critical hyperglycemia group (n=51) by their blood glucose level in hospital. Their fasting blood glucose (FBG), fasting insulin (FINS), IL-6, and CRP were detected for calculation of insulin sensitivity index (ISI). They were compared with 52 healthy people (healthy group). Results FBG, IL-6, and CRP were successively increased from healthy group, critical non-hyperglycemia group, to critical hyperglycemia group (F=124.402, 184.523, 695.431, P<0.01). Their FINS and ISI were successively decreased (F=12.795, 42.32, P<0.01). ISI was negatively correlated with IL-6 and CRP (r=-0.424, -0.532, P<0.01). Conclusion Severe stress hyperglycemia is correlated with decrease of insulin sensitivity, and inflammatory reaction is one of the causes of decreased insulin sensitivity in patients with critical disease.