CAJ | 학술논문

目的：探讨双酚A(BPA)与女童性早熟的关系。方法选择2012年8月至12月就诊的103例6~8岁性早熟女童，根据性早熟分类标准分为特发性中枢性性早熟(ICPP)组(n=47)及单纯乳房发育(PT)组(n=56)，选取同期同年龄乳房未发育女童53例为正常对照组。高效液相色谱串联质谱法(HPLC-MS-MS)测定血清BPA，酶联免疫法测定血清Kisspeptin，化学发光法测定血清性激素，比较和分析三组间的差异。结果 ICPP组和PT组的血清BPA检出率高于对照组，ICPP组血清BPA水平高于PT组及对照组，差异有统计学意义(P均<0.05)；ICPP组血清Kisspeptin水平也高于PT组及对照组，差异有统计学意义(P均<0.05)；ICPP组血清黄体生成素(LH)峰值及LH/卵泡刺激素(FSH)比值高于PT组，ICPP组及PT组血清雌二醇(E2)水平高于对照组，差异有统计学意义(P均<0.05)。三组的血清BPA水平与E2、LH峰值及LH/FSH比值有相关性(P<0.05)，与血清Kisspeptin水平及FSH峰值无相关性(P>0.05)。结论 BPA与女童ICPP发生有一定的相关性。
목적：탐토쌍분A(BPA)여녀동성조숙적관계。방법선택2012년8월지12월취진적103례6~8세성조숙녀동，근거성조숙분류표준분위특발성중추성성조숙(ICPP)조(n=47)급단순유방발육(PT)조(n=56)，선취동기동년령유방미발육녀동53례위정상대조조。고효액상색보천련질보법(HPLC-MS-MS)측정혈청BPA，매련면역법측정혈청Kisspeptin，화학발광법측정혈청성격소，비교화분석삼조간적차이。결과 ICPP조화PT조적혈청BPA검출솔고우대조조，ICPP조혈청BPA수평고우PT조급대조조，차이유통계학의의(P균<0.05)；ICPP조혈청Kisspeptin수평야고우PT조급대조조，차이유통계학의의(P균<0.05)；ICPP조혈청황체생성소(LH)봉치급LH/란포자격소(FSH)비치고우PT조，ICPP조급PT조혈청자이순(E2)수평고우대조조，차이유통계학의의(P균<0.05)。삼조적혈청BPA수평여E2、LH봉치급LH/FSH비치유상관성(P<0.05)，여혈청Kisspeptin수평급FSH봉치무상관성(P>0.05)。결론 BPA여녀동ICPP발생유일정적상관성。
Objective To study the relationship between bisphenol A and precocious puberty in 6-8 years girls. Meth-ods Atotal of 103 girls aged 6-8 years with precocious puberty in our Endocrine clinic from August to December 2012 were se-lected. According to the classiifcation standard of precocious puberty, girls are divided into idiopathic central precocious puberty (ICPP) group (n=47) and permature thelarche (PT) group (n=56), 53 girls with no puberty development were chosen as control group. BPA concentrations were determined with HPLC-MS-MS, sex hormones were determined with chemiluminescence meth-od and Kisspeptin concentrations were determined with ELISA, then the differences among the three groups were compared and the relationships between bisphenol A and sex hormones and Kisspeptin were analyzed. Results The BPA relevance ratio and concentration in ICPP group were higher than those of PT group and control group (P<0.05). The peak concentration of LH and LH/FSH in ICPP group were higher than those of PT group (P<0.05). The concentration of E2 in ICPP group and PT group were higher than that of control group (P<0.05). The concentration of Kisspeptin in ICPP group was higher than that of PT group and control group (P<0.05). There were no relationship between the concentrations of bisphenol A and Kisspeptin and FSH peak con-centration (P>0.05). There were correlations between the concentrations of BPA and E2 and LH peak concentration and LH/FSH (P<0.05). Conclusions There is a certain correlation between the concentrations of BPA and ICPP.