CAJ | 학술논문

目的：探讨高危型人乳头瘤病毒(HPV)感染与宫颈癌前病变以及宫颈癌的相关性。方法120例宫颈癌或是癌前病变患者,其中60例为宫颈癌前病变患者(癌前病变组),60例为宫颈癌患者(宫颈癌组),将其归为观察组,同时期60例阴道炎宫颈无细胞学改变的患者设为对照组。采用宫颈液基细胞学检查法与宫颈刮片、免疫组化予以筛查分析,同时还采用达安PCR-反向点杂交法检测,对比分析各组检测结果。结果高危型HPV总阳性率为56.67%,癌前病变组、宫颈癌组以及对照组患者的高危型HPV阳性率分别为65%、95%、10%,三组患者的阳性率对比差异具有统计学意义(P<0.05)。结论高危型HPV感染与宫颈癌前病变以及宫颈癌具有非常密切的关系,而在高危型HPV感染中以HPV16感染为主。
목적：탐토고위형인유두류병독(HPV)감염여궁경암전병변이급궁경암적상관성。방법120례궁경암혹시암전병변환자,기중60례위궁경암전병변환자(암전병변조),60례위궁경암환자(궁경암조),장기귀위관찰조,동시기60례음도염궁경무세포학개변적환자설위대조조。채용궁경액기세포학검사법여궁경괄편、면역조화여이사사분석,동시환채용체안PCR-반향점잡교법검측,대비분석각조검측결과。결과고위형HPV총양성솔위56.67%,암전병변조、궁경암조이급대조조환자적고위형HPV양성솔분별위65%、95%、10%,삼조환자적양성솔대비차이구유통계학의의(P<0.05)。결론고위형HPV감염여궁경암전병변이급궁경암구유비상밀절적관계,이재고위형HPV감염중이HPV16감염위주。
Objective To investigate the correlation between high-risk human papillomavirus (HPV) infection, precancerous lesions of cervix uteri and cervical cancer. Methods Among 120 patients with cervical cancer or precancerous lesions, there were 60 cases with precancerous lesions of cervix uteri (precancerous lesions group) and 60 cases with cervical cancer (cervical cancer group). They were chosen as the observation group, and another 60 patients without cytological changes of cervix uteri in colpitis were taken as the control group. Cervix uteri thinprep cytology test, cervical scraping smear, and immunohistochemcial method were applied for screening and analysis, and Ann PCR-reverse dot blot method was used for detection. Examination results were compared between the groups. Results The total positive rate of high-risk HPV was 56.67%, and the positive rates of high-risk HPV in precancerous lesions group, cervical cancer group and control group were respectively 65%, 95%, and 10%. The difference of positive rate between the three groups had statistical significance (P<0.05). Conclusion High-risk HPV has close relationship with precancerous lesions of cervix uteri and cervical cancer, and the infection of high-risk HPV was mainly in HPV16.