CAJ | 학술논문

目的：观察GFL方案(吉西他滨+5-氟尿嘧啶/亚叶酸钙)治疗FOLFOX方案(草酸铂+5-氟尿嘧啶/亚叶酸钙)失败晚期胃癌的疗效和不良反应。方法27例FOLFOX方案失败的晚期胃癌患者，应用GFL方案治疗2~4个周期。观察疗效。结果27例均可评价，有效率为33.3%，其中完全缓解0例(0)，部分缓解9例(33.3%)，稳定11例(40.7%)，进展7例(25.9%)，中位生存期5.2个月。不良反应主要为恶心呕吐、腹泻、骨髓抑制和肝功能损害，但均为轻度。结论 GFL方案治疗FOLFOX方案失败的晚期胃癌有一定疗效，不良反应可耐受，值得临床推广应用。
목적：관찰GFL방안(길서타빈+5-불뇨밀정/아협산개)치료FOLFOX방안(초산박+5-불뇨밀정/아협산개)실패만기위암적료효화불량반응。방법27례FOLFOX방안실패적만기위암환자，응용GFL방안치료2~4개주기。관찰료효。결과27례균가평개，유효솔위33.3%，기중완전완해0례(0)，부분완해9례(33.3%)，은정11례(40.7%)，진전7례(25.9%)，중위생존기5.2개월。불량반응주요위악심구토、복사、골수억제화간공능손해，단균위경도。결론 GFL방안치료FOLFOX방안실패적만기위암유일정료효，불량반응가내수，치득림상추엄응용。
Objective To observe the curative effect and adverse reactions of GFL regimen (gemcitabine+5-fluorouracil/calcium folinate) in the treatment of advanced gastric carcinoma with failed FOLFLX regimen (oxaliplatin+5-fluorouracil/calcium folinate). Methods There were 27 patients with advanced gastric carcinoma received failed FOLFOX regimen, and they all received GFL regimen for treatment for 2~4 period. Curative effect was observed. Results All the 27 cases could be evaluated, and their effective rate was 33.3%. There were 0 case of complete remission (0), 9 cases of partial remission (33.3%), 11 stable cases (40.7%), and 7 progressed cases (25.9%). The median survival time was 5.2 months. The main adverse reactions included nausea and emesis, diarrhea, myelosuppression, and liver function damage all at mild stage. Conclusion GFL regimen in the treatment of advanced gastric carcinoma with failed FOLFOX regimen has a certain effect and tolerable adverse reactions, and it is worthy of clinical promotion and application.