中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
8期
8-10
,共3页
颗粒细胞瘤%乳腺肿瘤%临床%病理
顆粒細胞瘤%乳腺腫瘤%臨床%病理
과립세포류%유선종류%림상%병리
Granular cell tumor%Breast tumor%Clinical%Pathology
目的：探讨发生于乳腺的颗粒细胞瘤患者的临床病理学特征、免疫表型、鉴别诊断及预后。方法收集2例发生于乳腺的颗粒细胞瘤患者的临床和病理资料，对其大体改变、组织形态和免疫表型进行回顾性分析，并复习文献和总结。结果2例均为女性，镜下瘤细胞境界清晰，胞质丰富，胞体宽大，内充满大量嗜酸性颗粒，呈浸润性生长。免疫组化S-100、CD68、神经特异性烯醇化酶(NSE)、波形蛋白(Vimentin)阳性表达，而细胞角蛋白(CK)、上皮膜抗原(EMA)、平滑肌肌动蛋白(SMA)阴性表达， Ki-67增殖指数<1%。结论乳腺颗粒细胞瘤较为少见，绝大部分为良性，临床及术中快速易误诊为癌，应提高对该疾病的认识，减少过度手术风险。
目的：探討髮生于乳腺的顆粒細胞瘤患者的臨床病理學特徵、免疫錶型、鑒彆診斷及預後。方法收集2例髮生于乳腺的顆粒細胞瘤患者的臨床和病理資料，對其大體改變、組織形態和免疫錶型進行迴顧性分析，併複習文獻和總結。結果2例均為女性，鏡下瘤細胞境界清晰，胞質豐富，胞體寬大，內充滿大量嗜痠性顆粒，呈浸潤性生長。免疫組化S-100、CD68、神經特異性烯醇化酶(NSE)、波形蛋白(Vimentin)暘性錶達，而細胞角蛋白(CK)、上皮膜抗原(EMA)、平滑肌肌動蛋白(SMA)陰性錶達， Ki-67增殖指數<1%。結論乳腺顆粒細胞瘤較為少見，絕大部分為良性，臨床及術中快速易誤診為癌，應提高對該疾病的認識，減少過度手術風險。
목적：탐토발생우유선적과립세포류환자적림상병이학특정、면역표형、감별진단급예후。방법수집2례발생우유선적과립세포류환자적림상화병리자료，대기대체개변、조직형태화면역표형진행회고성분석，병복습문헌화총결。결과2례균위녀성，경하류세포경계청석，포질봉부，포체관대，내충만대량기산성과립，정침윤성생장。면역조화S-100、CD68、신경특이성희순화매(NSE)、파형단백(Vimentin)양성표체，이세포각단백(CK)、상피막항원(EMA)、평활기기동단백(SMA)음성표체， Ki-67증식지수<1%。결론유선과립세포류교위소견，절대부분위량성，림상급술중쾌속역오진위암，응제고대해질병적인식，감소과도수술풍험。
Objective To explore the clinicopathologic features, immunophenotype, differential diagnosis, and prognosis of breast granular cell tumor. Methods Clinical and pathological data of 2 patients with breast granular cell tumor were collected, and their general change, tissue form , and immunophenotype were retrospectively analyzed. Related document and summary were reviewed. Results These two cases were female, and t heir tumor cell showed clear boundary, abundant cytoplasm, wide soma with plenty of eosinophilic granular, and infiltrative growth. The immunohistochemistry S-100, CD68, neuron specific enolase (NSE), and Vimentin had positive expressions, and cytokeratin (CK), epithelial membrane antigen (EMA), and smooth muscle actin (SMA) had negative expressions. The proliferation index of Ki-67 was<1%. Conclusion Breast granular cell tumor is rare, and most of it is benign. It can be easily misdiagnosed as cancer in clinic and operation. The understanding of this disease should be enhanced to reduce risk of excessive operation.
