CAJ | 학술논문

目的：调查不同人群小而密低密度脂蛋白胆固醇（sdLDL-C）水平，分析其与血脂组分的相关性。方法选取于该院进行体检和门诊就医人员共986例作为研究对象。其中血脂正常者654例，并根据性别和年龄划分；血脂增高者根据空腹 TG 和LDL-C 分为高 TG 组、高 LDL-C 组、联合增高组。测定上述人群血清 sdLDL-C、LDL-C、TG、TC、HDL-C、ApoAⅠ和 ApoB 水平，并分析 sdLDL-C 与 TG、TC、HDL-C、ApoAⅠ、ApoB 的相关性。结果男、女 sdLDL-C 70岁之后开始下降，差异有统计学意义（P ＜0．05）；sdLDL-C 水平总体均值男性高于女性，差异有统计学意义（P ＜0．05）。各血脂增高组 sdLDL-C 水平、sdLDL-C／LDL-C 均高于血脂正常组，差异均有统计学意义（P ＜0．05）。sdLDL-C 与 TC、TG、ApoB 呈正相关（r 分别为0．254、0．589、0．302），与HDL-C 和 ApoAⅠ呈负相关（r 分别为－0．421、－0．275、－0．311）。结论sdLDL-C 与 TC、TG、ApoB 呈正相关，与 HDL-C、ApoAI 呈负相关，能较准确地反映机体脂质代谢整体状况。
목적：조사불동인군소이밀저밀도지단백담고순（sdLDL-C）수평，분석기여혈지조분적상관성。방법선취우해원진행체검화문진취의인원공986례작위연구대상。기중혈지정상자654례，병근거성별화년령화분；혈지증고자근거공복 TG 화LDL-C 분위고 TG 조、고 LDL-C 조、연합증고조。측정상술인군혈청 sdLDL-C、LDL-C、TG、TC、HDL-C、ApoAⅠ화 ApoB 수평，병분석 sdLDL-C 여 TG、TC、HDL-C、ApoAⅠ、ApoB 적상관성。결과남、녀 sdLDL-C 70세지후개시하강，차이유통계학의의（P ＜0．05）；sdLDL-C 수평총체균치남성고우녀성，차이유통계학의의（P ＜0．05）。각혈지증고조 sdLDL-C 수평、sdLDL-C／LDL-C 균고우혈지정상조，차이균유통계학의의（P ＜0．05）。sdLDL-C 여 TC、TG、ApoB 정정상관（r 분별위0．254、0．589、0．302），여HDL-C 화 ApoAⅠ정부상관（r 분별위－0．421、－0．275、－0．311）。결론sdLDL-C 여 TC、TG、ApoB 정정상관，여 HDL-C、ApoAI 정부상관，능교준학지반영궤체지질대사정체상황。
Objective To survey small dense low-density lipoprotein cholesterol(sdLDL-C)distribution among different popula-tions,and analyze its relationship with lipid component.Methods 986 cases of people who underwent medical examination in the hospital were recruited in the study.There were 654 people with normal concentrations of serum blood lipids(normal blood lipids group),according to sex and age they were divided into groups.The people whose serum lipids concentrations increased above the normal range were divided into TG increasing group,LDL-C increasing group and joint increasing group according to the type of lip-ids componet increased.Serum sdLDL-C,LDL-C,TG,TC,HDL-C,ApoAⅠ and ApoB were determind in the people mentioned a-bove,and the correlation between sdLDL-C and TG,TC,HDL-C,ApoAⅠ,ApoB concentrations were analyzed.Results SdLDL-C began to decline after the age of 70,the difference was statistically significant(P <0.05 );the ensemble average of the males was higher than that of females,the difference was statistically significant(P <0.05).The serum sdLDL-C cocentrations of all the serum lipis increasing groups were significantly higher than those of normal blood lipids group,the difference was statistically significant (P <0.05 ).SdLDL-C concentrations were positively correlated with TC,TG,ApoB(r =0.254,0.589,0.302),and was negative correlated with HDL-C and ApoA Ⅰ (r = - 0.421,- 0.275,- 0.311 ).Conclusion There was a positive correlation between sdLDL-C and TC,TG,ApoB,and sdLDL-C was negatively correlated with HDL-C,ApoAⅠ,which can accurately reflect the overall status of lipid metabolism.