国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
4期
470-471,474
,共3页
原发性肝癌%甲胎蛋白%α1-抗胰蛋白酶%α1-酸性糖蛋白
原髮性肝癌%甲胎蛋白%α1-抗胰蛋白酶%α1-痠性糖蛋白
원발성간암%갑태단백%α1-항이단백매%α1-산성당단백
primary hepatic cancer%alpha-fetoprotein%alpha1-antitrypsin%alpha1-acid glycoprotein
目的：探讨血清α1-抗胰蛋白酶（AAT）、α1-酸性糖蛋白（AAG）和甲胎蛋白（AFP）单独及联合检测对原发性肝癌（PHC）诊断的价值。方法用速率散射比浊法对58例 PHC 患者，47例良性肝病患者及41例健康者进行血清 AAT、AAG 测定，同时应用化学发光法测定上述人群血清 AFP 水平。结果PHC 组 AAT、AAG、AFP 水平与对照组比较，差异有统计学意义（P ＜0．05）。AAT、AAG、AFP 检测对 PHC 诊断的灵敏度分别为82．8％、84．5％、72．4％，特异度分别为85．2％、90．9％、83．0％，联合检测对 PHC 诊断的灵敏度可提高到98．3％。结论血清 AAT、AAG 的检测可作为对 AFP 的补充，联合检测可提高对 PHC 的诊断率。
目的：探討血清α1-抗胰蛋白酶（AAT）、α1-痠性糖蛋白（AAG）和甲胎蛋白（AFP）單獨及聯閤檢測對原髮性肝癌（PHC）診斷的價值。方法用速率散射比濁法對58例 PHC 患者，47例良性肝病患者及41例健康者進行血清 AAT、AAG 測定，同時應用化學髮光法測定上述人群血清 AFP 水平。結果PHC 組 AAT、AAG、AFP 水平與對照組比較，差異有統計學意義（P ＜0．05）。AAT、AAG、AFP 檢測對 PHC 診斷的靈敏度分彆為82．8％、84．5％、72．4％，特異度分彆為85．2％、90．9％、83．0％，聯閤檢測對 PHC 診斷的靈敏度可提高到98．3％。結論血清 AAT、AAG 的檢測可作為對 AFP 的補充，聯閤檢測可提高對 PHC 的診斷率。
목적：탐토혈청α1-항이단백매（AAT）、α1-산성당단백（AAG）화갑태단백（AFP）단독급연합검측대원발성간암（PHC）진단적개치。방법용속솔산사비탁법대58례 PHC 환자，47례량성간병환자급41례건강자진행혈청 AAT、AAG 측정，동시응용화학발광법측정상술인군혈청 AFP 수평。결과PHC 조 AAT、AAG、AFP 수평여대조조비교，차이유통계학의의（P ＜0．05）。AAT、AAG、AFP 검측대 PHC 진단적령민도분별위82．8％、84．5％、72．4％，특이도분별위85．2％、90．9％、83．0％，연합검측대 PHC 진단적령민도가제고도98．3％。결론혈청 AAT、AAG 적검측가작위대 AFP 적보충，연합검측가제고대 PHC 적진단솔。
Objective To investigate the significance of single and combined detection of serum alpha1-antitrypsin,alpha1-acid glycoprotein and alpha-fetoprotein in the diagnosis of primary hepatic carcinoma(PHC).Methods Technique of rate nephelometry was used to detect the serum AAT and AAG in 58 PHC patients,47 patients with benign liver disease and 41 healthy people.The serum levels of AFP in the three groups were measured by chemiluminescence immunoassay.Results The levels of AAT,AAG and AFP in PHC group was higher than those in control group (P <0.05).The sensitivity of AAT,AAG and AFP in the diagnosis of PHC was 82.8%,84.5% and 72.4% respectively;The specificity was 85.2%,90.9% and 83.0% respectively.The combined measurement of the 3 makers could elevated the diagnostic specificity of PHC to 98.3%.Conclusion Detection of serum AAT and AAG can be a supplement to AFP.Combined measurement of the 3 makers might increase the diagnostic sensitivity of PHC.
