国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
4期
444-445,448
,共3页
肾综合征出血热%视黄醇结合蛋白%胱抑素 C
腎綜閤徵齣血熱%視黃醇結閤蛋白%胱抑素 C
신종합정출혈열%시황순결합단백%광억소 C
hemorrhagic fever with renal syndrome%retinal binding protein%cystain C
目的：探讨血清视黄醇结合蛋白（RBP）和胱抑素C（CysC）检测在肾综合征出血热（HFRS）所致肾损伤中的临床应用。方法分别检测124例初次确诊为 HFRS 的患者（患者组）和100例健康体检者（对照组）血清 RBP、CysC、尿素（Urea）和肌酐（Cr）的水平，使用 SPSS19．0软件对结果进行分析。结果RBP、CysC、Urea 和 Cr 的水平在 HFRS 患者的发热期明显升高，在少尿期达到高峰，随后逐渐降低，患者组各期与对照组比较，差异均有统计学意义（P ＜0．05）。HFRS 患者 RBP 与 Urea 和 Cr 均呈正相关（r 分别为0．826和0．892，P ＜0．05）；CysC 与 Urea 和 Cr 也均呈正相关（r 分别为0．841和0．924，P ＜0．05）。发热期RBP、CysC、Urea、Cr 阳性率分别为85．48％、95．16％、69．35％、83．06％，而在恢复期阳性率分别为67．74％、74．19％、46．77％和58．06％。结论RBP 和 CysC 是检测 HFRS 的良好指标，二者与 Urea、Cr 之间具有良好的相关性，值得在临床上推广。
目的：探討血清視黃醇結閤蛋白（RBP）和胱抑素C（CysC）檢測在腎綜閤徵齣血熱（HFRS）所緻腎損傷中的臨床應用。方法分彆檢測124例初次確診為 HFRS 的患者（患者組）和100例健康體檢者（對照組）血清 RBP、CysC、尿素（Urea）和肌酐（Cr）的水平，使用 SPSS19．0軟件對結果進行分析。結果RBP、CysC、Urea 和 Cr 的水平在 HFRS 患者的髮熱期明顯升高，在少尿期達到高峰，隨後逐漸降低，患者組各期與對照組比較，差異均有統計學意義（P ＜0．05）。HFRS 患者 RBP 與 Urea 和 Cr 均呈正相關（r 分彆為0．826和0．892，P ＜0．05）；CysC 與 Urea 和 Cr 也均呈正相關（r 分彆為0．841和0．924，P ＜0．05）。髮熱期RBP、CysC、Urea、Cr 暘性率分彆為85．48％、95．16％、69．35％、83．06％，而在恢複期暘性率分彆為67．74％、74．19％、46．77％和58．06％。結論RBP 和 CysC 是檢測 HFRS 的良好指標，二者與 Urea、Cr 之間具有良好的相關性，值得在臨床上推廣。
목적：탐토혈청시황순결합단백（RBP）화광억소C（CysC）검측재신종합정출혈열（HFRS）소치신손상중적림상응용。방법분별검측124례초차학진위 HFRS 적환자（환자조）화100례건강체검자（대조조）혈청 RBP、CysC、뇨소（Urea）화기항（Cr）적수평，사용 SPSS19．0연건대결과진행분석。결과RBP、CysC、Urea 화 Cr 적수평재 HFRS 환자적발열기명현승고，재소뇨기체도고봉，수후축점강저，환자조각기여대조조비교，차이균유통계학의의（P ＜0．05）。HFRS 환자 RBP 여 Urea 화 Cr 균정정상관（r 분별위0．826화0．892，P ＜0．05）；CysC 여 Urea 화 Cr 야균정정상관（r 분별위0．841화0．924，P ＜0．05）。발열기RBP、CysC、Urea、Cr 양성솔분별위85．48％、95．16％、69．35％、83．06％，이재회복기양성솔분별위67．74％、74．19％、46．77％화58．06％。결론RBP 화 CysC 시검측 HFRS 적량호지표，이자여 Urea、Cr 지간구유량호적상관성，치득재림상상추엄。
Objective To investigate the clinical application of serum retinal binding protein and cystain C determination in hem-orrhagic fever with renal syndrome(HFRS).Methods The serum concentrations of RBP,CysC,Urea and Cr were detected for 124 patients with HFRS(patients group)and 100 healthy people who underwent physical examination during the same period(control group),the date were analysed by SPSS19.0 software.Results The concentrations of RBP,CysC,Urea and Cr increased signifi-cantly in febrile stage of HFRS,arrived at peak in oliguria stage,and then declined gradually,there were statistically significant differences between each stage and negative control stage(P <0.05).RBP and CysC had a good positive correlation with Urea and Cr,the correlation coefficient between RBP and Urea or Cr were 0.826 and 0.892,respectively(P <0.05)while with CysC were 0. 841 and 0.924,respectively(P <0.05).The positive rates of RBP,CysC,Urea,Cr in febrile stage were 85.48%,95.16%,69.35%, 83.06% respectively,while in convalescent stage were 67.74%,74.19%,46.77% and 58.06% respectively.Conclusion RBP and CysC are good indicators for diagnosing HFRS,which also have good correlation with Urea and Cr,which are recommended in clini-cal application.
