CAJ | 학술논문

目的：探讨血清中降钙素原（PCT）、C反应蛋白（CRP）、前清蛋白（PA）及白细胞（WBC）计数在重症肺炎诊断中的意义。方法选取重症肺炎患者34例，非重症肺炎患者68例，健康体检者40例的血液样本为试验材料，测定其血清 PCT、CRP、PA 和外周血 WBC 的水平并进行统计分析。结果重症肺炎组血清 PCT、CRP、PA 水平和 WBC 分别为（24．07±34．77）ng／mL、（98．75±69．63）mg／L、（105．65±68．88）mg／L 和（12．64±7．62）×109／L，与其他组相比较差异均有统计学意义（P ＜0．05）。ROC 曲线分析发现 PCT 的灵敏度、特异度和 Youden 指数分别为64．7％、77．9％和0．426。结论PCT 可作为重症肺炎诊断的有效指标，联合检测 CRP 和 WBC 在重症肺炎的辅助诊断中具有一定的临床应用价值。
목적：탐토혈청중강개소원（PCT）、C반응단백（CRP）、전청단백（PA）급백세포（WBC）계수재중증폐염진단중적의의。방법선취중증폐염환자34례，비중증폐염환자68례，건강체검자40례적혈액양본위시험재료，측정기혈청 PCT、CRP、PA 화외주혈 WBC 적수평병진행통계분석。결과중증폐염조혈청 PCT、CRP、PA 수평화 WBC 분별위（24．07±34．77）ng／mL、（98．75±69．63）mg／L、（105．65±68．88）mg／L 화（12．64±7．62）×109／L，여기타조상비교차이균유통계학의의（P ＜0．05）。ROC 곡선분석발현 PCT 적령민도、특이도화 Youden 지수분별위64．7％、77．9％화0．426。결론PCT 가작위중증폐염진단적유효지표，연합검측 CRP 화 WBC 재중증폐염적보조진단중구유일정적림상응용개치。
Objective To evaluate the diagnostic value of procalcitonin(PCT),C-reactive protein(CRP),prealbumin(PA)and white blood cell (WBC)count measurements in patients with severe pneumonia.Methods The serum samples of 34 patients with severe pneumonia,68 non-severe pneumonia patients and 40 healthy volunteers were collected.Serum concentrations of PCT,CRP, PA and WBC count of all samples were determined.Results The levels of PCT,CRP,PA and WBC in patients with severe pneu-monia were (24.07±34.77)ng/mL,(98.75 ±69.63)mg/L,(105.65 ±68.88)mg/L,(12.64±7.62)×109/L,which were signifi-cantly higher than those in non-severe pneumonia patients and healthy group(P <0.05).According to ROC analysis,the sensitivity, specificity and Youden index of PCT were 64.7%,77.9%,0.426.Conclusion The level of serum PCT could be used as good bio-marker for severe pneumonia.Detection of PCT,CRP and WBC together plays an important role in the diagnosis of severe pneumo-nia.