CAJ | 학술논문

目的：：探讨调强放疗联合同步化疗治疗中晚期宫颈癌的疗效、不良反应、患者的生存情况及生活改善程度。方法：将2009年1月～2013年6月收治的晚期宫颈癌患者分为实验组(66例)和对照组(42例),实验组采用紫杉醇与顺铂方案联合同步调强放疗治疗,而对照组采用紫杉醇与顺铂方案联合同步三维适形放疗治疗。统计2组的疗效、1年生存率、1年无病生存率、不良反应情况、患者生活改善程度,利用x2检验分析相关数据。结果：实验组的完全缓解率为84.85%,高于对照组的71.43%(但P>0.05)。实验组急性消化道不良反应的发生率为45.45%,明显低于对照组的66.67%(P<0.05)。实验组发生贫血的概率为43.94%,明显低于对照组的64.29%(P<0.05)。实验组血小板异常的发生率为33.33%,明显低于对照的52.38%(P<0.05)。实验组发生放射性膀胱炎、放射性直肠炎概率分别为6.06%和10.61%,明显低于实验组的26.19%和30.95%,2组差别均有统计学意义(P<0.05)。结论：调强放疗联合同步化疗治疗中晚期宫颈癌的疗效明确,可以减少不良反应的发生率和提高患者的生活质量,但疗效和患者生存率同三维适形放疗方案无差别。
목적：：탐토조강방료연합동보화료치료중만기궁경암적료효、불량반응、환자적생존정황급생활개선정도。방법：장2009년1월～2013년6월수치적만기궁경암환자분위실험조(66례)화대조조(42례),실험조채용자삼순여순박방안연합동보조강방료치료,이대조조채용자삼순여순박방안연합동보삼유괄형방료치료。통계2조적료효、1년생존솔、1년무병생존솔、불량반응정황、환자생활개선정도,이용x2검험분석상관수거。결과：실험조적완전완해솔위84.85%,고우대조조적71.43%(단P>0.05)。실험조급성소화도불량반응적발생솔위45.45%,명현저우대조조적66.67%(P<0.05)。실험조발생빈혈적개솔위43.94%,명현저우대조조적64.29%(P<0.05)。실험조혈소판이상적발생솔위33.33%,명현저우대조적52.38%(P<0.05)。실험조발생방사성방광염、방사성직장염개솔분별위6.06%화10.61%,명현저우실험조적26.19%화30.95%,2조차별균유통계학의의(P<0.05)。결론：조강방료연합동보화료치료중만기궁경암적료효명학,가이감소불량반응적발생솔화제고환자적생활질량,단료효화환자생존솔동삼유괄형방료방안무차별。
Objective: To Investigate the curative effect, adverse reaction, survival conditions and mend matters of life of pa-tients in treatment metaphase or advanced stage of cervica cancer which was used by intensity-modulated radiotherapy with synchro-nous chemotherapy. Methods: Metaphase or advanced stage of cervica cancer patients who receive and cure from January 2009 to June 2013, They were divided into experimental group (66 cases) and control group (42 cases). Treatment Protocols of experi-mental group were paclitaxel and cisplatin combined with synchronous Intensity -Modulated radiotherapy, and control group were paclitaxel and cisplatin combined with three-dimensional conformal radiotherapy. The curative effect, 1 - year survival rate, 1 -year disease free surviva, adverse reaction, mend matters of life were be statisticsed, using chi-square test to analyze the data. Re-sults: The experimental group's complete remission rate was 84. 85%, which was higher than the control group's 71. 43% (but P>0. 05). The experimental group's incidence of acute gastrointestinal adverse reactions was 45. 45%, which was significantly lower than the control group's 66. 67% (P<0. 05). The experimental group's incidence of anemia was 43. 94%, which was significantly lower than the control group's 64. 29% (P<0. 05). The experimental group's incidence of platelets abnormal was 33. 33%, which significantly lower than the control group's 52. 38% (P<0. 05). The incidence of irradiation cystitis and factitial proctitis were 6. 06% and 10. 61% in experimental group, and the incidence of irradiation cystitis and factitial proctitis were 26. 19% and 30. 95%in control group, they were all significant differences between the two groups (P<0. 05). Conclusion: The therapeutic effect is clear-cut which use intensity-modulated radiotherapy to treat the metaphase or advanced stage of cervica cancer, this therapeutic schedule although could reduce the rate of adverse reaction and improve sufferer's living quality,but curative effect and patient surviv-al rates are indifference to three-dimensional conformal radiotherapy therapeutic schedule.