CAJ | 학술논문

磷酸肌醇－3羟激酶／蛋白激酶B（ PI3K／Akt）是一种经典的抗凋亡、促存活信号传导通路，在脑梗死、帕金森病、癫痫等神经系统疾病中发挥调节作用。孕酮是一种脂溶性甾体激素，对创伤性脑损伤、卒中、阿尔茨海默病等患者的神经保护有重要作用，其与p－Akt上调有关。本文通过收集讨论新生儿缺氧缺血性脑病（ HIE）、孕酮和PI3K／Akt的研究报道，以期为进一步探讨孕酮在HIE中的神经保护作用与 PI3 K／Akt信号通路的关系提供一定的理论依据。
린산기순－3간격매／단백격매B（ PI3K／Akt）시일충경전적항조망、촉존활신호전도통로，재뇌경사、파금삼병、전간등신경계통질병중발휘조절작용。잉동시일충지용성치체격소，대창상성뇌손상、졸중、아이자해묵병등환자적신경보호유중요작용，기여p－Akt상조유관。본문통과수집토론신생인결양결혈성뇌병（ HIE）、잉동화PI3K／Akt적연구보도，이기위진일보탐토잉동재HIE중적신경보호작용여 PI3 K／Akt신호통로적관계제공일정적이론의거。
Phosphatidylinositol 3 -kinase /protein kinase B ( PI3 K/Akt) is a classic anti -apoptotic and pro -survival signaling pathway, which plays a role in the regulation of cerebral infarction, Parkinson's dis-ease , epilepsy and other neurological diseases.Progesterone is one of the fat-soluble sex hormones, which has been proved to have neuro-pro-tective effect on nerological disease, such as brain injury, stroke and Alzheimer's disease, and it′s relevant to the up-regulation of p-Akt. Studies about the advance of neonatal hypoxic ischemic encephalopathy ( HIE) , progesterone and PI3K/Akt were collected and reviewed, antici-pating that it will provide theoretical basis for the further research of the relationship between progesterone and the signal pathway of PI3K/Akt in HIE.