CAJ | 학술논문

药源性严重过敏反应有难以预测、发作突然和致命性等特点，从而成为困扰临床药物使用的重要安全性因素。由于目前尚无严格的随机对照试验支持抢救药物的推荐，医生常根据临床经验用肾上腺素、抗组胺药和／或糖皮质激素应对突发的药源性严重过敏反应。血小板活化因子（ PAF）信号通路可为研究药源性严重过敏反应提供崭新的视角。本文将就药源性严重过敏反应的临床和流行病学特点、PAF通路、抗PAF通路的药物等进行概述。
약원성엄중과민반응유난이예측、발작돌연화치명성등특점，종이성위곤우림상약물사용적중요안전성인소。유우목전상무엄격적수궤대조시험지지창구약물적추천，의생상근거림상경험용신상선소、항조알약화／혹당피질격소응대돌발적약원성엄중과민반응。혈소판활화인자（ PAF）신호통로가위연구약원성엄중과민반응제공참신적시각。본문장취약원성엄중과민반응적림상화류행병학특점、PAF통로、항PAF통로적약물등진행개술。
The acute unpredictably life -threatening characteristic of drug-induced anaphylaxis hinders the safe use of clinical medication.In the absence of rigid randomized controlled trials supporting the recommen-dations for the treatment of immediate onset, doctors often treat drug-induced anaphylaxis with epinephrine, antihistamines and/or glucocorticoids.The researches in platelet activating factor signaling path-way could provide a novel perspective for drug-induced anaphylaxis.This review will briefly introduce the clinical and epidemiological characteristics of drug-induced anaphylaxis, platelet activating factor pathway and drugs targeting at this pathway.