CAJ | 학술논문

目的：探讨儿童肥胖与高尿酸血症的相关性。方法选取于该院就诊的2～17岁肥胖儿童316例作为肥胖组。另随机选取年龄及性别与之相匹配且体质量指数（BMI）正常的于本院进行健康体检且合格的儿童316例作为对照组。抽取空腹静脉血检测尿酸、葡萄糖（GLU）、总胆固醇（CHOL）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。结果与对照组儿童比较，肥胖组儿童的尿酸、CHOL、TG、LDL-C 水平均增高，而 HDL-C 水平降低，差异有统计学意义（P ＜0．05）。肥胖组中，高尿酸血症的检出率为24．68％，而对照组为9．49％，差异有统计学意义（P ＜0．05）。血尿酸水平与 TG、CHOL、LDL-C 水平呈正相关，与 HDL-C 呈负相关。结论肥胖可导致儿童血尿酸水平升高、血脂代谢异常。血尿酸水平与脂代谢异常具有相关性。
목적：탐토인동비반여고뇨산혈증적상관성。방법선취우해원취진적2～17세비반인동316례작위비반조。령수궤선취년령급성별여지상필배차체질량지수（BMI）정상적우본원진행건강체검차합격적인동316례작위대조조。추취공복정맥혈검측뇨산、포도당（GLU）、총담고순（CHOL）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）수평。결과여대조조인동비교，비반조인동적뇨산、CHOL、TG、LDL-C 수평균증고，이 HDL-C 수평강저，차이유통계학의의（P ＜0．05）。비반조중，고뇨산혈증적검출솔위24．68％，이대조조위9．49％，차이유통계학의의（P ＜0．05）。혈뇨산수평여 TG、CHOL、LDL-C 수평정정상관，여 HDL-C 정부상관。결론비반가도치인동혈뇨산수평승고、혈지대사이상。혈뇨산수평여지대사이상구유상관성。
Objective To investigate the correlation between hyperuricemia and obesity in children.Methods 316 children who went to the hospital for treatment of obesity were enrolled in the study as obesity group.Age and sex-matched children with normal body mass index(BMI)were randomly recruited as control group.Fasting venous blood samples were collected for the detection of serum uric acid(UA),glucose(GLU),total cholesterol(CHOL),triacylglycerol (TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C).Results Compared with the control group,serum concentrations of UA,CHOL, TG and LDL-C were higher while HDL-C was lower in obese children,the difference was statistically significant(P <0.05 ).The detection rate of hyperuricemia in obese children was 24.68%,and in control group was 9.49%,the difference was statistically sig-nificant(P <0.05 ).Serum UA concentration was positively correlated with TG,CHOL and LDL-C,negatively correlated with HDL-C.Conclusion Obesity can lead to higher serum UA concentration and abnormal lipid metabolism.The level of serum UA was correlated with abnormal lipid metabolism.