CAJ | 학술논문

目的：探讨葡萄糖-6-磷酸异构酶（G6PI）在类风湿性关节炎（RA）诊断中的价值。方法统计分析2011年8月至2013年8月该院共收治的130例 RA 患者的临床资料。同时，选取85例非 RA 的其他风湿病患者作为非 RA 组，60例健康者作为对照组。结果RA 组患者的 G6PI、抗环瓜氨酸肽（CCP）、类风湿因子（RF）水平均比非 RA 组和对照组高，差异有统计学意义（P ＜0．05）；非 RA 组患者 RF 水平比对照组高，差异有统计学意义（P ＜0．05）；RA 组患者 G6PI、抗 CCP 抗体、RF 检测的阳性率分别为67．70％（88／130）、52．30％（68／130）、75．38％（98／130），均高于非 RA 组和对照组相应检测指标的阳性率，差异有统计学意义（P ＜0．05）；非 RA 组患者 RF 水平比对照组高，差异有统计学意义（P ＜0．05）；G6PI 检测用于 RA 诊断的灵敏度、阴性预测值和约登指数均比抗 CCP 抗体和 RF 高，差异有统计学意义（P ＜0．05）。RA 患者的 G6PI 和抗 RF 水平呈正相关（r＝0．732，P ＜0．05）。结论G6PI 检测在类风湿关节炎的诊断中具有较高的价值。
목적：탐토포도당-6-린산이구매（G6PI）재류풍습성관절염（RA）진단중적개치。방법통계분석2011년8월지2013년8월해원공수치적130례 RA 환자적림상자료。동시，선취85례비 RA 적기타풍습병환자작위비 RA 조，60례건강자작위대조조。결과RA 조환자적 G6PI、항배과안산태（CCP）、류풍습인자（RF）수평균비비 RA 조화대조조고，차이유통계학의의（P ＜0．05）；비 RA 조환자 RF 수평비대조조고，차이유통계학의의（P ＜0．05）；RA 조환자 G6PI、항 CCP 항체、RF 검측적양성솔분별위67．70％（88／130）、52．30％（68／130）、75．38％（98／130），균고우비 RA 조화대조조상응검측지표적양성솔，차이유통계학의의（P ＜0．05）；비 RA 조환자 RF 수평비대조조고，차이유통계학의의（P ＜0．05）；G6PI 검측용우 RA 진단적령민도、음성예측치화약등지수균비항 CCP 항체화 RF 고，차이유통계학의의（P ＜0．05）。RA 환자적 G6PI 화항 RF 수평정정상관（r＝0．732，P ＜0．05）。결론G6PI 검측재류풍습관절염적진단중구유교고적개치。
Objective To investigate the value of G6PI in the diagnosis of rheumatoid arthritis(RA).Methods The clinical data of 130 cases of patients with RA treated in the hospital from August 2011 to August 2013 were statistically analyzed.In addition to that,85 non-RA patients with other rheumatic diseases were recruited as non-RA group and 60 healthy people were recruited as control group.Results Serum G6PI,anti-CCP antibodies and RF concentrations of RA group were significantly higher than those of non-RA group and control group(P <0.05),the RF concentrations of non-RA group was significantly higher than those of con-trol group(P <0.05).The positive rates of G6PI,anti-CCP antibodies and RF tests were 67.7%(88/130),52.3%(68/130)and 75.4% (98/130)respectively in RA group,which were significantly higher than those in non-RA and control group(P <0.05),the serum RF concentrations in non-RA group were significantly higher than control group(P <0.05).The sensitivity,negative predic-tive value and Youden index of G6PI were significantly higher than those of anti-CCP and RF(P <0.05).Serum G6PI concentra-tions of RA patients was positively correlated with those of RF(r=0.732,P <0.05).Conclusion G6PI detection can be used in the diagnosis of RA,and is of great value.