CAJ | 학술논문

目的：研究五味子对鲍曼不动杆菌，包括产金属β-内酰胺酶（MBL）细菌和不产 MBL 鲍曼不动杆菌的体外抗菌作用。方法对临床分离的75株鲍曼不动杆菌进行初步筛选，然后对这些菌株进行产 MBL 确证试验；检测75株鲍曼不动杆菌对14种抗菌药物的耐药情况；采用体外抑菌试验检测五味子水煎液对75株鲍曼不动杆菌（包括产 MBL 和不产 MBL 鲍曼不动杆菌）的 MIC。结果结果 MBL 确证试验表明筛选出的50株菌株中，有38株阳性，占试验菌株的76％（38／50）。结论五味子对鲍曼不动杆菌，特别是产 MBL 酶的鲍曼不动杆菌有一定的抑菌作用，可以将西药与五味子联合应用在抗鲍曼不动杆菌的治疗中。
목적：연구오미자대포만불동간균，포괄산금속β-내선알매（MBL）세균화불산 MBL 포만불동간균적체외항균작용。방법대림상분리적75주포만불동간균진행초보사선，연후대저사균주진행산 MBL 학증시험；검측75주포만불동간균대14충항균약물적내약정황；채용체외억균시험검측오미자수전액대75주포만불동간균（포괄산 MBL 화불산 MBL 포만불동간균）적 MIC。결과결과 MBL 학증시험표명사선출적50주균주중，유38주양성，점시험균주적76％（38／50）。결론오미자대포만불동간균，특별시산 MBL 매적포만불동간균유일정적억균작용，가이장서약여오미자연합응용재항포만불동간균적치료중。
Objective To investigate the antibacterial activity of Schisandra to Acinetobacter baumannii including metallo-β-lac-tamase(MBL)-producing and non-MBL-producing stains in vitro.Methods 75 strains of Acinetobacter baumannii were preliminary screened for clinical isolates of MBL-producing strains,to which confirmatory tests of MBL producing were performed.Drug sensi-tivities of the Acinetobacter baumannii to 14 antibacterial drugs were tested.In vitro antibacterial tests was adopted to determine the MIC of schisandra to 75 strains of Acinetobacter baumannii(including MBL and non-MBL-producing Acinetobacter baumannii).Re-sults MBL confirmatory test showed that among the 50 strains selected 38 strains were positive accounted for 76% (38/50).Con-clusion Schisandra has some antibacterial effect on Acinetobacter baumannii especially MBL-producing Acinetobacter baumannii, and can be combined with western medicine in the treatment of Acinetobacter baumannii infection.