国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
3期
371-372
,共2页
强直性脊柱炎%人类白细胞抗原 B27%流式细胞术
彊直性脊柱炎%人類白細胞抗原 B27%流式細胞術
강직성척주염%인류백세포항원 B27%류식세포술
ankylosing spondylitis%human leukocyte antigen B27%flow cytometry
目的:探讨 HLA-B27抗原表达与强直性脊柱炎(AS)的相关性,及其对 AS 诊断和鉴别诊断的意义。方法采用流式细胞术检测人类白细胞抗原 B27(HLA-B27),纳入研究的包括354例疑似 AS 患者、35例确诊 AS 患者和30例确诊类风湿性关节炎(RA)患者。结果354例疑似 AS 患者的 HLA-B27总阳性率为22.0%,确诊 AS 患者 HLA-B27的阳性率为85.7%,均高于RA 组(P <0.05)。AS 患者中男性占77.1%,女性占22.9%,且发病年龄主要集中在青壮年时期;AS 患者 HLA-B27抗原检测用于AS 诊断的灵敏度为85.7%,特异度为100.0%。结论HLA-B27抗原的检测对 AS 患者的早期诊断和鉴别诊断具有重要意义。
目的:探討 HLA-B27抗原錶達與彊直性脊柱炎(AS)的相關性,及其對 AS 診斷和鑒彆診斷的意義。方法採用流式細胞術檢測人類白細胞抗原 B27(HLA-B27),納入研究的包括354例疑似 AS 患者、35例確診 AS 患者和30例確診類風濕性關節炎(RA)患者。結果354例疑似 AS 患者的 HLA-B27總暘性率為22.0%,確診 AS 患者 HLA-B27的暘性率為85.7%,均高于RA 組(P <0.05)。AS 患者中男性佔77.1%,女性佔22.9%,且髮病年齡主要集中在青壯年時期;AS 患者 HLA-B27抗原檢測用于AS 診斷的靈敏度為85.7%,特異度為100.0%。結論HLA-B27抗原的檢測對 AS 患者的早期診斷和鑒彆診斷具有重要意義。
목적:탐토 HLA-B27항원표체여강직성척주염(AS)적상관성,급기대 AS 진단화감별진단적의의。방법채용류식세포술검측인류백세포항원 B27(HLA-B27),납입연구적포괄354례의사 AS 환자、35례학진 AS 환자화30례학진류풍습성관절염(RA)환자。결과354례의사 AS 환자적 HLA-B27총양성솔위22.0%,학진 AS 환자 HLA-B27적양성솔위85.7%,균고우RA 조(P <0.05)。AS 환자중남성점77.1%,녀성점22.9%,차발병년령주요집중재청장년시기;AS 환자 HLA-B27항원검측용우AS 진단적령민도위85.7%,특이도위100.0%。결론HLA-B27항원적검측대 AS 환자적조기진단화감별진단구유중요의의。
Objective To investigate the correlation between the expression of human leukocyte antigen B27(HLA-B27)antigen and ankylosing spondylitis(AS),and its implications for the diagnosis and differential diagnosis of AS.Methods Flow cytometry was used to detect HLA-B27.354 suspected AS patients,35 patients final diagnosed with AS and 30 patients diagnosed with rheu-matoid arthritis(RA)were enrolled in the study.Results The positive rate of HLA-B27 in 354 patients with suspected AS was 22.0%,in patients diagnosed with AS was 85.7%,which was higher than the RA group(P <0.05).In AS patients,Males accoun-ted for 77.1%,females accounted for 22.9%,and the patients′age mainly concentrated in youth.The sensitivity and specificity of HLA-B27 test was 85.7% and 100.0% respectively in the diagnosis of AS.Conclusion HLA-B27 antigen detection is important for early diagnosis and differential diagnosis of AS patients.