CAJ | 학술논문

目的：调查妊娠期女性外阴阴道念珠菌病（VVC）的发病率，并对分离的念珠菌进行鉴定和药物敏感性分析。方法选取于该院产科门诊就诊的745例妊娠期女性，记录其临床一般资料及分泌物镜检和培养结果。对妊娠期女性分泌物真菌感染及药物敏感性状况进行分析。结果妊娠期女性 VVC 的发病率为10．20％，VVC 复发者占18．50％。76例 VVC 患者中白色念珠菌、光滑念珠菌、克柔念珠菌、热带念珠菌和其他念珠菌感染者分别占80．26％、8．95％、3．95％、1．32％和6．58％。61株白色念珠菌对两性霉素 B 和5-氟胞嘧啶均敏感，对氟康唑、伊曲康唑、伏立康唑的耐药率分别为7．89％、6．58％、9．21％。光滑念珠菌、热带念珠菌和其他念珠菌对所用抗菌药物均敏感。结论VVC 是妊娠女性的常见感染，白色念珠菌仍然是主要致病菌，其次为光滑念珠菌。念珠菌对常用抗真菌药物中的两性霉素 B 和5-氟胞嘧啶较为敏感，对氟康唑、伊曲康唑和伏立康唑存在一定程度的耐药性。
목적：조사임신기녀성외음음도념주균병（VVC）적발병솔，병대분리적념주균진행감정화약물민감성분석。방법선취우해원산과문진취진적745례임신기녀성，기록기림상일반자료급분비물경검화배양결과。대임신기녀성분비물진균감염급약물민감성상황진행분석。결과임신기녀성 VVC 적발병솔위10．20％，VVC 복발자점18．50％。76례 VVC 환자중백색념주균、광활념주균、극유념주균、열대념주균화기타념주균감염자분별점80．26％、8．95％、3．95％、1．32％화6．58％。61주백색념주균대량성매소 B 화5-불포밀정균민감，대불강서、이곡강서、복립강서적내약솔분별위7．89％、6．58％、9．21％。광활념주균、열대념주균화기타념주균대소용항균약물균민감。결론VVC 시임신녀성적상견감염，백색념주균잉연시주요치병균，기차위광활념주균。념주균대상용항진균약물중적량성매소 B 화5-불포밀정교위민감，대불강서、이곡강서화복립강서존재일정정도적내약성。
Objective To investigate the vulvaginal candidiasis(VVC)incidence in pregnant women,identify the candida species and analyze the drug resistance of isolated strains.Methods Candida isolation,sample cultivation,species identification and drug susceptibility test were performed for VVC patients.Seven hundred and forty-five samples were collected.Results The incidence of VVC was 10.20%,and the recurrence of VVC was 18.5%.The proportion of C.albicans,C.glabrata,C.krusei,C.tropicalis and other candida were 80.26%,8.95%,3.95%,1.32% and 6.58% respectively.C.albicans was susceptible to amphotericin and 5-flucytosine,the susceptibility for fluconzazole,itroconazole and voriconazole were 7.89%,6.58% and 9.21% respectively.C.gla-brata,C.krusei,C.tropicalis,and other candida were susceptible to those antifungal drugs.Conclusion VVC was an usual infection among pregnant women,C.albicans was the major species,followed by C.glabrata.The resistance of amphotericin and 5-flucytosine were lower,the Candida were resistant to fluconzazole,itroconazole and voriconazole in certain extent.