CAJ | 학술논문

目的：探讨血糖、糖化血红蛋白（HbA1c）、糖化清蛋白（GA）水平检测在急性脑梗死患者中的临床意义。方法选取127例急性脑梗死患者，以102例健康人作为对照。测定并比较患者与健康人静脉空腹血糖、HbA1c 和 GA 水平。分析不同神经功能受损程度、病灶个数、大小、预后情况与空腹血糖、HbA1c 和 GA 水平的相关性。结果急性脑梗死患者空腹血糖、HbA1c 与GA 水平都高于健康人，差异有统计学意义（P ＜0．05）；神经功能缺损程度严重、梗死体积大、预后差的患者 GA 与 HbA1c 水平更高，差异均有统计学意义（P ＜0．05）。多个梗死病灶的患者 GA 水平高于单个梗死病灶患者，差异有统计学意义（P ＜0．05），但HbA1c 水平的差异无统计学意义（P ＞0．05）。空腹血糖水平在不同神经功能受损程度、病灶个数、大小、预后的患者中比较，差异均无统计学意义（P ＞0．05）。结论血糖、HbA1c 与、GA 水平与急性脑梗死患者的神经功能受损程度、病情轻重、预后密切相关，检测这些指标对急性脑梗死患者具有重要意义。
목적：탐토혈당、당화혈홍단백（HbA1c）、당화청단백（GA）수평검측재급성뇌경사환자중적림상의의。방법선취127례급성뇌경사환자，이102례건강인작위대조。측정병비교환자여건강인정맥공복혈당、HbA1c 화 GA 수평。분석불동신경공능수손정도、병조개수、대소、예후정황여공복혈당、HbA1c 화 GA 수평적상관성。결과급성뇌경사환자공복혈당、HbA1c 여GA 수평도고우건강인，차이유통계학의의（P ＜0．05）；신경공능결손정도엄중、경사체적대、예후차적환자 GA 여 HbA1c 수평경고，차이균유통계학의의（P ＜0．05）。다개경사병조적환자 GA 수평고우단개경사병조환자，차이유통계학의의（P ＜0．05），단HbA1c 수평적차이무통계학의의（P ＞0．05）。공복혈당수평재불동신경공능수손정도、병조개수、대소、예후적환자중비교，차이균무통계학의의（P ＞0．05）。결론혈당、HbA1c 여、GA 수평여급성뇌경사환자적신경공능수손정도、병정경중、예후밀절상관，검측저사지표대급성뇌경사환자구유중요의의。
Objective To investigate blood glucose,HbA1c and GA levels in patients with acute cerebral infarction.Methods 129 patients with acute cerebral infarction and 102 healthy persons were recruited.Blood glucose,HbA1c and GA levels were com-pared between acute infarction patients and healthy people.The correlation of blood glucose,HbA1c and GA with different degree of neurological deficits,number and sizes of infarct lesions and prognosis were explored.Results Fasting plasma glucose,HbA1c and GA levels in patients with acute cerebral infarction were significantly higher than in healthy people(P <0.05).GA and HbA1c levels were higher in patients with more severe degree of neurological deficit,larger infarct volume and poorer prognosis,and the differences were statistically significant (P <0.05).GA level was significantly higher in patients with multifocal infraction than pa-tients with single(P <0.05),however,there were no differences of HbA1c between the two groups.No significantly differences of fasting blood glucose were found among the patients classified with neurological deficit,number and sizes of infarct lesion and prog-nosis(P >0.05).Conclusion Blood glucose,HbA1c and GA levels were closely related with neurological deficit,severity and prog-nosis of acute cerebral infarction,thus determination of these indicators is of important clinical significance.