CAJ | 학술논문

目的：探讨三阴性乳腺癌与非三阴性乳腺癌患者间睾酮和雄激素受体（AR）水平的差异及临床意义。方法按照纳入标准选取该院经病理确证为原发性乳腺癌的患者，共92例女性患者，其中三阴性乳腺癌42例，非三阴性乳腺癌50例，统计分析三阴性与非三阴性乳腺组患者年龄、组织学分级、病理分期、血清睾酮水平和 AR 的差异。结果三阴性乳腺癌组和非三阴性乳腺癌组比较，三阴性乳腺癌组血清睾酮水平低于非三阴性乳腺癌组，差异有统计学意义（P ＜0．05）；三阴性乳腺癌组 AR 阳性率为57％，非三阴性乳腺癌 AR 阳性率为82％，差异有统计学意义（P ＜0．05）。结论雄激素和 AR 可能成为三阴性乳腺癌新的治疗突破点。
목적：탐토삼음성유선암여비삼음성유선암환자간고동화웅격소수체（AR）수평적차이급림상의의。방법안조납입표준선취해원경병리학증위원발성유선암적환자，공92례녀성환자，기중삼음성유선암42례，비삼음성유선암50례，통계분석삼음성여비삼음성유선조환자년령、조직학분급、병리분기、혈청고동수평화 AR 적차이。결과삼음성유선암조화비삼음성유선암조비교，삼음성유선암조혈청고동수평저우비삼음성유선암조，차이유통계학의의（P ＜0．05）；삼음성유선암조 AR 양성솔위57％，비삼음성유선암 AR 양성솔위82％，차이유통계학의의（P ＜0．05）。결론웅격소화 AR 가능성위삼음성유선암신적치료돌파점。
Objective To investigate the difference of serum testosterone and androgen receptor(AR)concentrations between triple negative breast cancer patients and non-triple negative breast cancer patients and its clinical significance.differences and clini-cal significance.Methods According to the inclusion criteria,a total of 92 female patients were enrolled in the study including 42 patients with triple negative breast cancer and 50 patients with non-triple negative breast cancer.The patients recruited all seeked medical advice in hospital and diagnosed with primary breast cancer by using pathological method.Age,histological grade,patholog-ical stage,serum testosterone and AR concentrations were compared between triple negative breast and non-triple-negative group and statistically analyzed.Results Compared between triple negative breast and non-triple-negative group,the serum testosterone concentrations of triple negative breast was lower and the difference were statistically different(P <0.05);AR-positive rate of triple negative breast cancer group was 57%,AR-positive rate of non-triple-negative breast cancer was 82%,the difference was statistical-ly significant(P <0.05).Conclusion Androgen and AR may be a prognostic therapeutic target in triple negative breast cancer.