CAJ | 학술논문

目的：探讨温经祛瘀方对子宫内膜病变不孕症患者体外受精—胚胎移植（ IVF-ET）周期子宫内膜形态变化与临床妊娠的影响。方法将60例接受IVF-ET的子宫内膜病变不孕症患者随机分为观察组（30例）和对照组（30例），对照组单纯宫腔镜下诊刮送病理检查后采用常规控制性超促排卵方案，观察组在对照组治疗的基础上辨证运用温经祛瘀方进行中药干预，观察两组患者IVF-ET周期临床与实验室相关检测指标变化。结果与对照组比较，观察组可以显著提高子宫内膜病变不孕症患者HCG注射日A型子宫内膜形态＞降低C型或不均质子宫内膜的出现（P均＜0．05）；观察组生化妊娠率高于对照组（P＜0．05）。两组促性腺激素使用时间、用量、获卵数、受精率、优胚率、移植胚胎数、HCG注射日子宫内膜厚度、血清雌二醇、孕酮、黄体生成素、周期取消率比较差异均无统计学意义（ P均＞0．05）。结论 IVF-ET周期温经祛瘀方能有效改善子宫内膜病变不孕症患者的子宫内膜形态，提高胚胎种植率与临床妊娠率。
목적：탐토온경거어방대자궁내막병변불잉증환자체외수정—배태이식（ IVF-ET）주기자궁내막형태변화여림상임신적영향。방법장60례접수IVF-ET적자궁내막병변불잉증환자수궤분위관찰조（30례）화대조조（30례），대조조단순궁강경하진괄송병리검사후채용상규공제성초촉배란방안，관찰조재대조조치료적기출상변증운용온경거어방진행중약간예，관찰량조환자IVF-ET주기림상여실험실상관검측지표변화。결과여대조조비교，관찰조가이현저제고자궁내막병변불잉증환자HCG주사일A형자궁내막형태＞강저C형혹불균질자궁내막적출현（P균＜0．05）；관찰조생화임신솔고우대조조（P＜0．05）。량조촉성선격소사용시간、용량、획란수、수정솔、우배솔、이식배태수、HCG주사일자궁내막후도、혈청자이순、잉동、황체생성소、주기취소솔비교차이균무통계학의의（ P균＞0．05）。결론 IVF-ET주기온경거어방능유효개선자궁내막병변불잉증환자적자궁내막형태，제고배태충식솔여림상임신솔。
Objective To explore the effect of Wenjingquyufang on endometrial pattern and pregnancy rate of in infertil -ity patients with endometrial pathological changes for in vitro fertilization and embryo transfer (IVF-ET).Methods A total of 60 infertility patients with endometrial pathological changes for IVF-ET were divided into Chinese traditional medicine group (n=30) and control group(n=30) randomly.The control group patients take controlled ovarian hyperstimulation after they had hysteroscopy and curettage for Pathological examination .The patients of Chinese traditional medicine group had taken Wenjingquyufang for a week during hysteroscopy and curettage finished and menstruation .The data of clinical and laborary were compared between the two groups .Results There was significantly different on A and C endometrial pattern between two groups (P<0.05).Their biochemical pregnancy rate was different (P<0.05).The stimulation days and dose of gonado-tropic hormone, average numbers of retrieved oocytes and fertilization rate , high quality embryo rate and the number of embry-os transferred were no statistical significance compared with their inter-group(all P>0.05).On the day of human chorionic gonadotropin injection , the depth of endometrium , the serum level of estradiol , progesterone , luteinizing hormone and the number of cancel transfer were no significant difference between two groups (all P>0.05).Conclusion Wenjingquyufang can improve endometrial pattern , embryo implantation rate and clinical pregnancy rate in infertility patients with endometrial pathological changes for in vitro fertilization and embryo transfer .It has no influence on controlled ovarian hyperstimulation .