中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
4期
264-266
,共3页
程李健%徐慧%殷萍%兰允平
程李健%徐慧%慇萍%蘭允平
정리건%서혜%은평%란윤평
阿托品%脑电双频指数%气管插管%靶控输注%丙泊酚
阿託品%腦電雙頻指數%氣管插管%靶控輸註%丙泊酚
아탁품%뇌전쌍빈지수%기관삽관%파공수주%병박분
atropine%bispctral index%endotracheal intubation%target-controlled infusion%propofol
目的：评价阿托品对靶控输注诱导气管插管时脑电双频指数（ BIS）的影响。方法入选行择期腹腔镜胆囊切除手术患者70例，随机分为阿托品组和对照组，每组各35例。2组均用靶控输注法诱导，首先微泵输入丙泊酚与瑞芬太尼，4 min后，阿托品组患者静脉推注阿托品10μg? kg－1，对照组推注同等容量0．9％NaCl，10 min后开始气管插管。记录诱导开始15 min内患者的平均动脉压（ MAP）、心率（ HR）和BIS。结果与插管前即刻的BIS值比较，插管后1 min 2组的BIS值均明显增高（P＜0．05）。插管后3，5 min，阿托品组BIS值较对照组明显增高[（52．83±4．00） vs （48．92±3．00） ， （48．81±4．00） vs （46．53±4．20）]（P＜0．05）。插管前2 min、插管前即刻和插管后3，5 min，2组患者的MAP和HR比较差异有统计学意义（P＜0．05）。结论靶控输注诱导气管插管时用阿托品会引起BIS值升高。
目的：評價阿託品對靶控輸註誘導氣管插管時腦電雙頻指數（ BIS）的影響。方法入選行擇期腹腔鏡膽囊切除手術患者70例，隨機分為阿託品組和對照組，每組各35例。2組均用靶控輸註法誘導，首先微泵輸入丙泊酚與瑞芬太尼，4 min後，阿託品組患者靜脈推註阿託品10μg? kg－1，對照組推註同等容量0．9％NaCl，10 min後開始氣管插管。記錄誘導開始15 min內患者的平均動脈壓（ MAP）、心率（ HR）和BIS。結果與插管前即刻的BIS值比較，插管後1 min 2組的BIS值均明顯增高（P＜0．05）。插管後3，5 min，阿託品組BIS值較對照組明顯增高[（52．83±4．00） vs （48．92±3．00） ， （48．81±4．00） vs （46．53±4．20）]（P＜0．05）。插管前2 min、插管前即刻和插管後3，5 min，2組患者的MAP和HR比較差異有統計學意義（P＜0．05）。結論靶控輸註誘導氣管插管時用阿託品會引起BIS值升高。
목적：평개아탁품대파공수주유도기관삽관시뇌전쌍빈지수（ BIS）적영향。방법입선행택기복강경담낭절제수술환자70례，수궤분위아탁품조화대조조，매조각35례。2조균용파공수주법유도，수선미빙수입병박분여서분태니，4 min후，아탁품조환자정맥추주아탁품10μg? kg－1，대조조추주동등용량0．9％NaCl，10 min후개시기관삽관。기록유도개시15 min내환자적평균동맥압（ MAP）、심솔（ HR）화BIS。결과여삽관전즉각적BIS치비교，삽관후1 min 2조적BIS치균명현증고（P＜0．05）。삽관후3，5 min，아탁품조BIS치교대조조명현증고[（52．83±4．00） vs （48．92±3．00） ， （48．81±4．00） vs （46．53±4．20）]（P＜0．05）。삽관전2 min、삽관전즉각화삽관후3，5 min，2조환자적MAP화HR비교차이유통계학의의（P＜0．05）。결론파공수주유도기관삽관시용아탁품회인기BIS치승고。
Objective To evaluate the influence of atropine on the bis-pectral index( BIS) response to endotracheal intubation induced by target controlled infusion. Methods Seventy patients who were scheduled laparoscopic cholecystectomy were randomly divided into atropine group and control group, 35 patients in each group.First, patients in two groups were induced by target controlled infusion, with propofol and remifentanil pumped.After four minutes, patients received either atro-pine ( 10 μg? kg-1 ) or an equal volume of 0.9% NaCl injection.Tra-cheal intubation was performed 10 minutes after anesthetic induction. The data of BIS, mean arterial pressure( MAP) and heart rate( HR) were recorded during the 15 -minute anesthesia induction. Results BIS values of the two groups 1 minute after intubation were significantly in-creased compared with those before intubation ( P <0.05 ) .Compared with control group, BIS values in atropine group were significantly higher three and five minutes after intubation [(52.83 ±4.00) vs (48.8 ±4.00), (48.9 ±4.00) vs (46.53 ±4.20)] (P<0.05).There were statistical differences between two groups in the data of MAP and HR 2 minutes before intubation, immediately before intubation, as well as three and five minutes after intubation, respectively.Conclusion Atropine can increase BIS value response to endotracheal intubation induced by target controlled infusion.
