临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
4期
627-629,630
,共4页
肺癌%晚期%脑转移%预后
肺癌%晚期%腦轉移%預後
폐암%만기%뇌전이%예후
lung cancer,advanced stage%brain metastases%prognosis
目的：探讨影响非小细胞肺癌( non-small cell lung cancer, NSCLC)脑转移患者生存时间的因素。方法回顾性分析我院收治的NSCLC脑转移并行头颅放疗患者302例,其中资料完整者171例进行分析。采用SPSS13.0统计软件行影响生存期的单因素及多因素Cox风险比例模型回归分析。探讨患者的临床特征及放疗方式等因素对患者生存期的影响。结果全组患者中位生存期为8．8(95%CI：7．2~10．3)个月；单因素分析显示：PS评分( P=0．002)、脑转移数量( P=0．023)、脑转移时间( P =0．031)、放疗方式( P =0．041)和肺癌是否切除(P=0．002)与患者预后有关；Cox多元回归分析显示：PS评分(P=0．04)和肺癌是否手术切除(P=0．04)为脑转移患者独立预后因素而与脑转移数量(P=0．65)、脑转移时间(P=0．71)、放疗方式(P=0．91)等因素无关。结论 NSCLC脑转移整体预后较差,手术切除肺部肿瘤且体力评分较好患者预后相对较好。
目的：探討影響非小細胞肺癌( non-small cell lung cancer, NSCLC)腦轉移患者生存時間的因素。方法迴顧性分析我院收治的NSCLC腦轉移併行頭顱放療患者302例,其中資料完整者171例進行分析。採用SPSS13.0統計軟件行影響生存期的單因素及多因素Cox風險比例模型迴歸分析。探討患者的臨床特徵及放療方式等因素對患者生存期的影響。結果全組患者中位生存期為8．8(95%CI：7．2~10．3)箇月；單因素分析顯示：PS評分( P=0．002)、腦轉移數量( P=0．023)、腦轉移時間( P =0．031)、放療方式( P =0．041)和肺癌是否切除(P=0．002)與患者預後有關；Cox多元迴歸分析顯示：PS評分(P=0．04)和肺癌是否手術切除(P=0．04)為腦轉移患者獨立預後因素而與腦轉移數量(P=0．65)、腦轉移時間(P=0．71)、放療方式(P=0．91)等因素無關。結論 NSCLC腦轉移整體預後較差,手術切除肺部腫瘤且體力評分較好患者預後相對較好。
목적：탐토영향비소세포폐암( non-small cell lung cancer, NSCLC)뇌전이환자생존시간적인소。방법회고성분석아원수치적NSCLC뇌전이병행두로방료환자302례,기중자료완정자171례진행분석。채용SPSS13.0통계연건행영향생존기적단인소급다인소Cox풍험비례모형회귀분석。탐토환자적림상특정급방료방식등인소대환자생존기적영향。결과전조환자중위생존기위8．8(95%CI：7．2~10．3)개월；단인소분석현시：PS평분( P=0．002)、뇌전이수량( P=0．023)、뇌전이시간( P =0．031)、방료방식( P =0．041)화폐암시부절제(P=0．002)여환자예후유관；Cox다원회귀분석현시：PS평분(P=0．04)화폐암시부수술절제(P=0．04)위뇌전이환자독립예후인소이여뇌전이수량(P=0．65)、뇌전이시간(P=0．71)、방료방식(P=0．91)등인소무관。결론 NSCLC뇌전이정체예후교차,수술절제폐부종류차체력평분교호환자예후상대교호。
Objective To evaluate the prognosis factors for non-small cell lung cancer patients with brain metastases. Methods The clinical data of 302 patients of non-small cell lung cancer patients with brain metastases were reviewed, and only 171 cases with adequate survival data were analyzed respectively. The clinical factors and treatment procedures were analyzed by univariate analysis and Cox regression to evaluate the effect on prognosis. Re-sults The overall median survival time for this group patients was 8. 8 (95%CI:7. 2~10. 3) months. The univari-ate analysis demonstrated the PS score (P=0. 002), number of brain metastasis (P=0. 023), time of brain metas-tases ( P=0. 031 ) , radiotherapy methods ( P=0. 041 ) and tumor resection in lung ( P=0. 002 ) were associated with the prognosis. In the Cox regression analysis, the PS score (P=0. 04) and lung surgery (P=0. 04) were inde-pendent prognosis factors for NSCLC patients with brain metastases, but they had no relationship with number of brain metastasis (P=0. 65), time of brain metastases (P=0. 71) and radiotherapy methods (P=0. 91). Conclusion The general prognosis of NSCLC patients with brain metastases is poor. Patients with lung carcinoma resection and good quality of physical activity may have a superior prognosis.
