CAJ | 학술논문

目的：探讨妊娠期肝内胆汁淤积症胆汁酸对新生儿并发症及预后的影响。方法选取2012年1月~2014年1月入院治疗的68例妊娠期肝内胆汁淤积症孕妇为肝内胆汁淤积症组,同期正常孕妇68例为健康对照组。观察比较两组孕妇胆汁酸、丙氨酸氨基转移酶,新生儿的胎龄、出生质量和宫内窘迫的发生率。结果肝内胆汁淤积症组孕妇的胆汁酸和丙氨酸氨基转移酶水平均高于健康对照组,差异有统计学意义(t=13.0045,P=0.0000；t=7.2784,P=0.0000)；肝内胆汁淤积症组新生儿的胎龄和出生质量均明显低于健康对照组,差异有统计学意义(t=21.1026,P=0.0000；t=16.6681,P=0.0000)；肝内胆汁淤积症组宫内窘迫发生率高于健康对照组,差异有统计学意义(字2=4.1676,P=0.0412)。结论妊娠期肝内胆汁淤积症孕妇的胆汁酸水平显著升高,可导致宫内窘迫发生率升高,新生儿胎龄短、出生质量低,整体预后效果不佳。
목적：탐토임신기간내담즙어적증담즙산대신생인병발증급예후적영향。방법선취2012년1월~2014년1월입원치료적68례임신기간내담즙어적증잉부위간내담즙어적증조,동기정상잉부68례위건강대조조。관찰비교량조잉부담즙산、병안산안기전이매,신생인적태령、출생질량화궁내군박적발생솔。결과간내담즙어적증조잉부적담즙산화병안산안기전이매수평균고우건강대조조,차이유통계학의의(t=13.0045,P=0.0000；t=7.2784,P=0.0000)；간내담즙어적증조신생인적태령화출생질량균명현저우건강대조조,차이유통계학의의(t=21.1026,P=0.0000；t=16.6681,P=0.0000)；간내담즙어적증조궁내군박발생솔고우건강대조조,차이유통계학의의(자2=4.1676,P=0.0412)。결론임신기간내담즙어적증잉부적담즙산수평현저승고,가도치궁내군박발생솔승고,신생인태령단、출생질량저,정체예후효과불가。
Objective To explore the influence of bile acid in patients with intrahepatic cholestasis of pregnancy on neonatal complications and prognosis. Methods 68 cases of pregnant women with intrahepatic cholestasis of pregnancy in our hospital from January 2012 to January 2014 were selected as intrahepatic cholestasis of pregnancy group,68 nor-mal pregnant women at the same time were selected as healthy control group.The bile acid,alanine aminotransferase, neonates with gestational age,neonatal birth quality and the incidence of fetal distress of the two groups was observed and compared. Results The level of bile acid and alanine aminotransferase in the intrahepatic cholestasis of pregnancy group was higher than that in the healthy control group,the difference was significance (t=13.0045,P=0.0000;t=7.2784, P=0.0000).The level of neonates with gestational age and neonatal birth quality in the intrahepatic cholestasis of preg-nancy group was lower than that in the healthy control group,the difference was significant (t=21.1026,P=0.0000;t=16.6681,P=0.0000).The incidence of fetal distress in the intrahepatic cholestasis of pregnancy group was higher than that in the healthy control group,the difference was significant (χ2=4.1676,P=0.0412). Conclusion The bile acid level of pregnant women with intrahepatic cholestasis of pregnancy increases significantly,which can lead to higher incidence of intrauterine distress,neonatal has shorter gestational age and lower birth quality,the overall prognosis is poor.