CAJ | 학술논문

目的：研究左炔诺孕酮宫内缓释系统对子宫腺肌症患者肝功能、血脂及性激素水平的影响，评估其安全性，以指导临床应用。方法对左炔诺孕酮宫内缓释系统治疗的43例子宫腺肌症患者，检测其治疗前后肝功能(ALT、AST)、血脂(TC、HDL、LDL)、血清性激素水平(FSH、LH、E2)的变化。结果43例子宫腺肌症患者的肝功能(ALT、AST)、血脂(TC、HDL、LDL)及血清性激素水平(FSH、LH、E2)在治疗前后均在正常范围内，且治疗前后差异无统计学意义。结论左炔诺孕酮宫内缓释系统治疗子宫腺肌症对肝功能、血脂代谢及血清性激素水平无影响，安全性高。
목적：연구좌결낙잉동궁내완석계통대자궁선기증환자간공능、혈지급성격소수평적영향，평고기안전성，이지도림상응용。방법대좌결낙잉동궁내완석계통치료적43례자궁선기증환자，검측기치료전후간공능(ALT、AST)、혈지(TC、HDL、LDL)、혈청성격소수평(FSH、LH、E2)적변화。결과43례자궁선기증환자적간공능(ALT、AST)、혈지(TC、HDL、LDL)급혈청성격소수평(FSH、LH、E2)재치료전후균재정상범위내，차치료전후차이무통계학의의。결론좌결낙잉동궁내완석계통치료자궁선기증대간공능、혈지대사급혈청성격소수평무영향，안전성고。
Objective To study the impact of levonorgestrel releasing intrauterine system (LNG-IUS)on liver function, blood lipid and sex hormone levels in patients with adenomyosis and evaluate its safety in order to guide clinical ap-plication. Methods Forty-three patients with adenomyosis were treated by LNG-IUS.The change of liver function in-cluding alanine aminotransferase(ALT)and aspartate aminotransferase(AST),blood lipid containing total cholesterol(TC), high density lipoprotein(HDL),low density lipoprotein(LDL),serum sex hormone levels including follicle-stimulating hor-mone(FSH),luteinizing hormone (LH),estradiol (E2)before and after treatment were tested. Results Among these 43 pa-tients with adenomyosis,the value of liver function(ALT and AST),blood lipid(TC,HDL,LDL)and serum sex hormone level (FSH,LH and E2)before and after therapy all belonged to normal limits,and there was no statistical difference pretherapy and post-treatment. Conclusion LNG-IUS has no influence on liver function,blood lipid metabolism or serum sex hor-mone levels,it is high in safety.