CAJ | 학술논문

目的：观察小剂量奥氮平联合帕罗西汀治疗脑卒中后抑郁的临床效果。方法将96例脑卒中后抑郁患者随机分为两组，治疗组(48例)给予小剂量奥氮平联合帕罗西汀治疗，对照组(48例)给予帕罗西汀治疗，疗程为3个月。分别于治疗前后应用汉密尔顿抑郁量表(HAMD)评估抑郁症状的改善情况，应用不良反应量表(TESS)评估药物不良反应。结果治疗后，治疗组的HAMD评分明显低于对照组，差异有统计学意义(P<0.05)。治疗组的总有效率95.8%、对照组为87.5%，治疗组的疗效明显优于对照组，差异有统计学意义(P<0.05)。治疗组的不良反应发生率为18.8%，对照组为16.7%，两组比较，差异无统计学意义(P跃0.05)。两组的TESS评分比较差异无统计学意义(P跃0.05)。结论小剂量奥氮平联合帕罗西汀治疗脑卒中后抑郁的效果明显优于单用帕罗西汀，且无明显不良反应，值得临床推广。
목적：관찰소제량오담평연합파라서정치료뇌졸중후억욱적림상효과。방법장96례뇌졸중후억욱환자수궤분위량조，치료조(48례)급여소제량오담평연합파라서정치료，대조조(48례)급여파라서정치료，료정위3개월。분별우치료전후응용한밀이돈억욱량표(HAMD)평고억욱증상적개선정황，응용불량반응량표(TESS)평고약물불량반응。결과치료후，치료조적HAMD평분명현저우대조조，차이유통계학의의(P<0.05)。치료조적총유효솔95.8%、대조조위87.5%，치료조적료효명현우우대조조，차이유통계학의의(P<0.05)。치료조적불량반응발생솔위18.8%，대조조위16.7%，량조비교，차이무통계학의의(P약0.05)。량조적TESS평분비교차이무통계학의의(P약0.05)。결론소제량오담평연합파라서정치료뇌졸중후억욱적효과명현우우단용파라서정，차무명현불량반응，치득림상추엄。
Objective To observe the clinical effect of small dose olanzapine combined with paroxetine in the treatment of post-stroke depression. Methods Ninety-six patients with post-stroke depression were randomly divided into the two groups,the treatment group (n=48) was treated with small dose olanzapine combined with paroxetine,the control group (n=48) was treated with paroxetine,the course of treatment lasted 3 months.Hamilton Depression Scale (HAMD) was ap-plied before and after therapy in order to evaluate the improvement of depressive symptom.Treatment emergent symptom scale (TESS) was used to evaluate the adverse drug reaction. Results After therapy,HAMD score in the treatment group was lower than that in the control group with a statistical difference (P<0.05).The total effective rate in the treatment group was 95.8%,while in the control group,the total effective rate was 87.5%,the curative effect of the treatment group was better than the control group with a statistical difference (P<0.05).The incidence rate of adverse reaction in the treatment group was 18.8%,it was 16.7% in the control group,and there was no statistical difference in the two groups (P>0.05).There was no statistical difference of TESS score in the two groups (P>0.05). Conclusion The effect of small dose olanzapine combined with paroxetine treating post-stroke depression is obviously better than simple using paroxe-tine without obvious adverse reaction.It is worthy of clinical expansion.