CAJ | 학술논문

目的：评价盐酸戊乙奎醚注射液治疗急性有机磷中毒的临床效果。方法选取2010年2月~2013年2月本院收治的50例急性有机磷农药中毒的患者作为研究对象，将其随机分为对照组与观察组，各25例，分别给予阿托品和盐酸戊乙奎醚注射液治疗。结果观察组的用药次数少于对照组，住院时间、症状消失时间、血胆碱酯酶活力恢复时间均短于对照组(P<0.05)。观察组心动过速(>100/min)、尿潴留及视力模糊的发生率显著低于对照组，但谵妄、躁动的发生率均显著高于对照组(P<0.05)。结论盐酸戊乙奎醚注射液救治急性有机磷农药中毒的效果良好，用药安全性较高，值得临床推广。
목적：평개염산무을규미주사액치료급성유궤린중독적림상효과。방법선취2010년2월~2013년2월본원수치적50례급성유궤린농약중독적환자작위연구대상，장기수궤분위대조조여관찰조，각25례，분별급여아탁품화염산무을규미주사액치료。결과관찰조적용약차수소우대조조，주원시간、증상소실시간、혈담감지매활력회복시간균단우대조조(P<0.05)。관찰조심동과속(>100/min)、뇨저류급시력모호적발생솔현저저우대조조，단섬망、조동적발생솔균현저고우대조조(P<0.05)。결론염산무을규미주사액구치급성유궤린농약중독적효과량호，용약안전성교고，치득림상추엄。
Objective To evaluate the effect of penehyclidine hydrochloride injection in the treatment of acute organophosphorus poisoning. Methods From February 2010 to February 2013,50 patients with acute organophosphorus pesticide treated in our hospital were selected as the research objects and they were divided into the control group (n=25) and observation group (n=25).Atropine and penehyclidine hydrochloride injection was adopted in the control group and observation group respectively. Results The number of drugs in the observation group was fewer than that in the control group,hospital stay, the symptoms disappear time,the blood cholinesterase activity recovery time in the observa-tion group in the observation group was shorter than that in the control group respectively (P<0.05).The incidence rate of heartbeat tachycardia (>100/min),retention of urine and blurred vision was significantly lower than that in the con-trol group,but the incidence rate of delirium,restlessness was significantly higher than that of the control group respec-tively (P<0.05). Conclusion The effect of penehyclidine hydrochloride injection in the treatment of acute organophos-phorus poisoning is good,and the medication safety is higher. It is worthy of clinical promotion.