CAJ | 학술논문

目的：对比不同肺表面活性物质治疗早产儿呼吸窘迫综合征的临床效果。方法以医院新生儿科90例呼吸窘迫综合征早产儿作为研究对象,均行机械通气治疗,根据肺表面活性物质用药类型将其分为A组(45例)和B组(45例),分别取牛肺表面活性物质和猪肺表面活性物质治疗,观察两组患者治疗前后的血气指标,记录机械通气时间,评估两组患者的预后。结果两组患者用药前、用药12 h后的血气指标差异无统计学意义(P>0.05),但用药12 h后,PaO2、pH均显著高于用药前,PaCO2显著低于用药前,差异具有统计学意义(P<0.05)。B组的持续正压通气时间为(4.06±0.62)d,显著短于A组的(5.14±0.55)d,差异有统计学意义(P<0.05)。 B组的并发症发生率和死亡率分别为13.33%、4.44%,与A组比较,差异无统计学意义(P>0.05)。结论两种肺表面活性物质均能够改善早产儿的呼吸窘迫症状,但猪肺表面活性物质用药方便,可缩短患儿的机械通气时间。
목적：대비불동폐표면활성물질치료조산인호흡군박종합정적림상효과。방법이의원신생인과90례호흡군박종합정조산인작위연구대상,균행궤계통기치료,근거폐표면활성물질용약류형장기분위A조(45례)화B조(45례),분별취우폐표면활성물질화저폐표면활성물질치료,관찰량조환자치료전후적혈기지표,기록궤계통기시간,평고량조환자적예후。결과량조환자용약전、용약12 h후적혈기지표차이무통계학의의(P>0.05),단용약12 h후,PaO2、pH균현저고우용약전,PaCO2현저저우용약전,차이구유통계학의의(P<0.05)。B조적지속정압통기시간위(4.06±0.62)d,현저단우A조적(5.14±0.55)d,차이유통계학의의(P<0.05)。 B조적병발증발생솔화사망솔분별위13.33%、4.44%,여A조비교,차이무통계학의의(P>0.05)。결론량충폐표면활성물질균능구개선조산인적호흡군박증상,단저폐표면활성물질용약방편,가축단환인적궤계통기시간。
Objective To compare the clinical effect of two kinds of different pulmonary surfactant treating respiratory distress syndrome in premature infants. Methods 90 premature infants with respiratory distress syndrome in department of neonatal pediatrics of hospital were selected as research objects,and they were given mechanical ventilation.They were divided into the group A (n=45) and group B (n=45) according to patient’s medication type,and they were treated with bovine pulmonary surfactant and porcine pulmonary surfactant.Blood gas indexes before and after treatment in pa-tients of the two groups were observed,machine ventilation time was recorded,and the prognosis of the patients in the two groups was evaluated. Results There was no statistical difference of the blood gas indexes before administration and after 12 hours administration in the two groups (P>0.05),but after 12 hours administration,PaO2,pH were signifi-cantly higher than before treatment,PaCO2 was significantly lower than that before treatment in the two groups with sta-tistical difference (P<0.05).The continuous positive airway pressure ventilation time of the group B [(4.06±0.62) d] was significantly shorter than those of the group A [(5.14±0.55) d] and there was a statistical difference (P<0.05).The inci-dence rate of complicatios and mortality of the group B was 13.33%,4.44%respectively,and there was no statistical dif-ference compared with the group A (P>0.05). Conclusion Two pulmonary surfactant can improve respiratory distress symptoms of the premature infants,but porcine pulmonary surfactant medication is convenience,can shorten the duration of mechanical ventilation in infants.