CAJ | 학술논문

目的：观察喹硫平联合丙戊酸钠治疗双相障碍躁狂的有效性及安全性。方法选取本院2012年3月~2014年3月收治的80例双相障碍躁狂患者，将其随机分成研究组和对照组，各40例。对照组给予喹硫平治疗，研究组给予喹硫平联合丙戊酸钠治疗，连续治疗8周。采用Bech-Rafaelsen躁狂量表(BRMS)评估治疗效果，比较两组的总有效率、不良反应发生率。结果治疗后4、8周，研究组的BRMS评分明显低于对照组，差异有统计学意义(P<0.05)；治疗后8周，两组的总有效率比较，差异无统计学意义(P跃0.05)；两组的不良反应发生率比较，差异有统计学意义(P<0.05)。结论喹硫平联合丙戊酸钠对双相障碍躁狂的效果确切，安全可靠，值得临床推广应用。
목적：관찰규류평연합병무산납치료쌍상장애조광적유효성급안전성。방법선취본원2012년3월~2014년3월수치적80례쌍상장애조광환자，장기수궤분성연구조화대조조，각40례。대조조급여규류평치료，연구조급여규류평연합병무산납치료，련속치료8주。채용Bech-Rafaelsen조광량표(BRMS)평고치료효과，비교량조적총유효솔、불량반응발생솔。결과치료후4、8주，연구조적BRMS평분명현저우대조조，차이유통계학의의(P<0.05)；치료후8주，량조적총유효솔비교，차이무통계학의의(P약0.05)；량조적불량반응발생솔비교，차이유통계학의의(P<0.05)。결론규류평연합병무산납대쌍상장애조광적효과학절，안전가고，치득림상추엄응용。
Objective To observe the effectiveness and safety of quetiapine combined with sodium valproate in the treatment of bipolar disorder manic. Methods From March 2012 to March 2014,80 patients with bipolar disorder manic treated in our hospital were selected and randomly divided into the research group (n=40) and control group (n=40).The control group was given quetiapined,while the research group was given quetiapine combined with sodium valproate.The course of treatment lasted 8 weeks.The therapeutic effect was evaluated by Bech-Rafaelsen mania scale (BRMS).The total effective rate,the incidence rate of adverse reaction in the two groups were compared. Results After 4,8 weeks treatment,BRMS score of the research group was greatly lower than that in the control group with a statistical difference (P<0.05). After 8 weeks treatment,there was no statistical difference of the total effective rate in the two groups (P>0.05). There was a statistical difference of the incidence rate of adverse reaction in the two groups (P<0.05). Conclusion Quetiapine combined with sodium valproate in the treatment of bipolar disorder manic obtains a definite therapeutic effect.It is safe and reliable,and is worthy of clinical expansion and application.