CAJ | 학술논문

目的：比较巴曲酶与地塞米松治疗中高频下降突发性耳聋的效果。方法选取2011年3月~2013年11月在本院耳鼻咽喉科就诊并且确诊为中高频下降突发性耳聋患者114例,采用随机数字表法将患者分为两组,各57例。两组均给予基础治疗,观察组在此基础上加用蛋白酶类药物巴曲酶治疗,对照组加用糖皮质激素类药物地塞米松治疗。比较两组的治疗效果及不良反应发生率。结果观察组的总有效率、痊愈率和显效率均高于对照组,且其显效率(字2=7.255,P=0.007)和总有效率(字2=12.120,P=0.000)差异均有统计学意义。观察组的不良反应发生率为7.0%,显著低于对照组的22.8%,差异有统计学意义(字2=5.600,P=0.018)。结论巴曲酶治疗中高频下降突发性耳聋的效果好,不良反应少,临床上推荐在常规治疗的基础上静脉使用巴曲酶。
목적：비교파곡매여지새미송치료중고빈하강돌발성이롱적효과。방법선취2011년3월~2013년11월재본원이비인후과취진병차학진위중고빈하강돌발성이롱환자114례,채용수궤수자표법장환자분위량조,각57례。량조균급여기출치료,관찰조재차기출상가용단백매류약물파곡매치료,대조조가용당피질격소류약물지새미송치료。비교량조적치료효과급불량반응발생솔。결과관찰조적총유효솔、전유솔화현효솔균고우대조조,차기현효솔(자2=7.255,P=0.007)화총유효솔(자2=12.120,P=0.000)차이균유통계학의의。관찰조적불량반응발생솔위7.0%,현저저우대조조적22.8%,차이유통계학의의(자2=5.600,P=0.018)。결론파곡매치료중고빈하강돌발성이롱적효과호,불량반응소,림상상추천재상규치료적기출상정맥사용파곡매。
Objective To compare the effect of batroxobin and dexamethasone treating sudden deafness of medium-high frequency decline. Methods 114 patients sudden deafness of medium-high frequency decline treated and diagnosed in department of ear-nose-throat of our hospital from March 2011 to November 2013 were selected and were randomly divided into the two groups,and there were 57 cases in each group.The patients in the two groups were firstly given basic treatment,and then the patients in the observation group were treated with batroxobin (a kind of protease drugs) on the basis of the basic treatment,while the patients in the control group were treated with dexamethasone (a kind of glucocorticoid drugs) on the basis of the basic treatment.The treatment effect and the incidence rate of adverse reaction of the two groups were compared. Results The total effective rate,the cure rate and markedly effective rate of observation group was higher than those of control group,and its total effective rate (χ2=12.120, P=0.000),markedly effective rate (χ2=7.255, P=0.007) had statistical difference.The incidence rate of adverse reaction in the observation group (7.0%) was obviously lower than that in the control group (22.8%),and there was a statistical difference of the two groups (χ2=5.600, P=0.018). Conclusion Batroxobin treating sudden deafness of medium-high frequency decline has good effect with fewer adverse reaction.Batroxobin for ntravenous use is clinically recommended on the basis of routine therapy.