CAJ | 학술논문

目的：探讨氯氮平联合碳酸锂对难治性精神分裂症患者临床脑电图的影响。方法抽取河南省精神病院2010年1月~2014年1月接受住院治疗的难治性精神分裂症患者80例，将其随机分为两组，对照组40例单纯给予氯氮平治疗，观察组40例给予氯氮平联合碳酸锂治疗，所有患者进行为期8周的治疗，比较两组的治疗效果。结果观察组的总有效率为82.5%，对照组为65.0%，两组的临床疗效比较差异有统计学意义(P<0.05)；观察组治疗后的脑电图异常率为32.5%，对照组为22.5%，两组比较差异无统计学意义(P>0.05)；观察组在治疗期间发生3例轻微椎体外系反应(视力模糊、嗜睡、烦躁、失眠、体重增加)及2例出现肝功能异常等，对照组出现2例肝功能轻度异常、1例白细胞轻度减少、2例体重增加、1例流涎和嗜睡、2例烦躁不安等，两者的不良反应发生情况差异无统计学意义(P>0.05)。结论氯氮平联合碳酸锂治疗难治性精神分裂症能够有效改善患者的临床症状，提高治疗效果，且未发生严重的不良反应，值得临床推广应用。
목적：탐토록담평연합탄산리대난치성정신분렬증환자림상뇌전도적영향。방법추취하남성정신병원2010년1월~2014년1월접수주원치료적난치성정신분렬증환자80례，장기수궤분위량조，대조조40례단순급여록담평치료，관찰조40례급여록담평연합탄산리치료，소유환자진행위기8주적치료，비교량조적치료효과。결과관찰조적총유효솔위82.5%，대조조위65.0%，량조적림상료효비교차이유통계학의의(P<0.05)；관찰조치료후적뇌전도이상솔위32.5%，대조조위22.5%，량조비교차이무통계학의의(P>0.05)；관찰조재치료기간발생3례경미추체외계반응(시력모호、기수、번조、실면、체중증가)급2례출현간공능이상등，대조조출현2례간공능경도이상、1례백세포경도감소、2례체중증가、1례류연화기수、2례번조불안등，량자적불량반응발생정황차이무통계학의의(P>0.05)。결론록담평연합탄산리치료난치성정신분렬증능구유효개선환자적림상증상，제고치료효과，차미발생엄중적불량반응，치득림상추엄응용。
Objective To investigate the influence of clozapine combined with lithium carbonate on clinical electroen-cephalogram (EEG) of patients with refractory schizophrenia. Methods 80 patients with refractory schizophrenia treated in Mental Hospital of Henan Province from January 2010 to January 2014 were selected,and they were divided into the two groups.The control group (n=40) was only given clozapine,the observation group (n=40) was given clozapine com-bined with lithium carbonate.All patients were treated for 8 weeks.The treatment effect in the two groups was compared. Results The total effective rate was 82.5% in the observation group,and it was 65.0% in the control group,and there was a statistical difference of clinical curative effect in the two groups (P<0.05);abnormal rate of EEG in the observa-tion group after treatment was 32.5%,it was 22.5% in the control group,and there was no statistical difference of abnor-mal rate of EEG in the two groups (P>0.05);there were 3 cases with mild extrapyramidal reaction (blurred vision,drowsi-ness,irritability,insomnia,weight gain) and 2 cases with abnormal liver function and so on in the observation group,there were 2 cases with mild abnormal liver function,1 case with mild reduction of white blood cell and 2 cases with weight gain,1 case with salivation and lethargy,2 cases with irritability and so on,and there was no staistical differences of oc-currence of adverse reaction in the two groups (P>0.05). Conclusion Clozapine combined with lithium carbonate treat-ing refractory schizophrenia can effectively improve the clinical symptoms,improve the therapeutic effect,and does not occur serious adverse reaction.It is worthy of clinical promotion and application.