山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2015年
3期
18-20
,共3页
杨茜%张海雄%韩雪梅%韩仰东
楊茜%張海雄%韓雪梅%韓仰東
양천%장해웅%한설매%한앙동
2型糖尿病%大血管病变%高敏C反应蛋白
2型糖尿病%大血管病變%高敏C反應蛋白
2형당뇨병%대혈관병변%고민C반응단백
Type 2 diabetes%large vascular lesions%hypersensitive c-reactive protein
目的:观察2型糖尿病(T2DM)伴大血管病变患者血清高敏C 反应蛋白(hs-CRP)水平变化,并探讨其意义。方法选取45例T2DM合并大血管病变患者(A组)、45例单纯T2DM患者(B组)及40例健康体检者(C组),采用透射比浊法检测血清hs-CRP,采用全自动生化仪测定血脂,采用微柱法测定血糖。对A组患者血清hs-CRP与血糖、血脂的关系采用Pearson法进行相关性分析。结果 A、B、C组血清hs-CRP分别为(4.12±2.15)、(2.16±0.92)、(0.62±0.34)ng/mL,糖化血红蛋白(HbA1c)分别为11.09%±1.67%、9.27%±1.21%、4.17%±0.41%,空腹血糖(FPG)分别为(11.86±3.91)、(10.97±3.36)、(4.58±0.76)mmol/L,餐后2小时血糖(PPG)分别为(15.91±2.34)、(13.79±3.29)、(6.16±0.83)mmol/L,三组间血清hs-CRP比较,P均<0.01;A、B组与C组HbA1c、FPG、PPG比较,P均<0.01。 A、B、C组TC分别为(5.84±0.56)、(5.47±0.34)、(3.31±0.25)mmol/L,TG分别为(2.27±0.27)、(2.18±0.23)、(1.21±0.19)mmol/L,LDL-C分别为(4.46±0.91)、(4.34±0.67)、(2.07±0.31) mmol/L,HDL-C分别为(1.17±0.37)、(1.21±0.42)、(1.51±0.62)mmol/L,A、B组TC、TG、LDL-C、HDL-C与C组比较,P均<0.01。相关分析结果显示,血清hs-CRP与HbA1c、FPG、PPG、TC、TG、LDL-C均呈正相关( r分别为0.3685、0.4393、0.3847、0.3069、0.3431、0.4045,P均<0.01),与HDL-C呈负相关(r=-0.2393,P<0.01)。结论 T2DM伴大血管病变患者血清hs-CRP水平明显升高;hs-CRP可能参与了T2DM血管病变的病理过程。
目的:觀察2型糖尿病(T2DM)伴大血管病變患者血清高敏C 反應蛋白(hs-CRP)水平變化,併探討其意義。方法選取45例T2DM閤併大血管病變患者(A組)、45例單純T2DM患者(B組)及40例健康體檢者(C組),採用透射比濁法檢測血清hs-CRP,採用全自動生化儀測定血脂,採用微柱法測定血糖。對A組患者血清hs-CRP與血糖、血脂的關繫採用Pearson法進行相關性分析。結果 A、B、C組血清hs-CRP分彆為(4.12±2.15)、(2.16±0.92)、(0.62±0.34)ng/mL,糖化血紅蛋白(HbA1c)分彆為11.09%±1.67%、9.27%±1.21%、4.17%±0.41%,空腹血糖(FPG)分彆為(11.86±3.91)、(10.97±3.36)、(4.58±0.76)mmol/L,餐後2小時血糖(PPG)分彆為(15.91±2.34)、(13.79±3.29)、(6.16±0.83)mmol/L,三組間血清hs-CRP比較,P均<0.01;A、B組與C組HbA1c、FPG、PPG比較,P均<0.01。 A、B、C組TC分彆為(5.84±0.56)、(5.47±0.34)、(3.31±0.25)mmol/L,TG分彆為(2.27±0.27)、(2.18±0.23)、(1.21±0.19)mmol/L,LDL-C分彆為(4.46±0.91)、(4.34±0.67)、(2.07±0.31) mmol/L,HDL-C分彆為(1.17±0.37)、(1.21±0.42)、(1.51±0.62)mmol/L,A、B組TC、TG、LDL-C、HDL-C與C組比較,P均<0.01。相關分析結果顯示,血清hs-CRP與HbA1c、FPG、PPG、TC、TG、LDL-C均呈正相關( r分彆為0.3685、0.4393、0.3847、0.3069、0.3431、0.4045,P均<0.01),與HDL-C呈負相關(r=-0.2393,P<0.01)。結論 T2DM伴大血管病變患者血清hs-CRP水平明顯升高;hs-CRP可能參與瞭T2DM血管病變的病理過程。
목적:관찰2형당뇨병(T2DM)반대혈관병변환자혈청고민C 반응단백(hs-CRP)수평변화,병탐토기의의。방법선취45례T2DM합병대혈관병변환자(A조)、45례단순T2DM환자(B조)급40례건강체검자(C조),채용투사비탁법검측혈청hs-CRP,채용전자동생화의측정혈지,채용미주법측정혈당。대A조환자혈청hs-CRP여혈당、혈지적관계채용Pearson법진행상관성분석。결과 A、B、C조혈청hs-CRP분별위(4.12±2.15)、(2.16±0.92)、(0.62±0.34)ng/mL,당화혈홍단백(HbA1c)분별위11.09%±1.67%、9.27%±1.21%、4.17%±0.41%,공복혈당(FPG)분별위(11.86±3.91)、(10.97±3.36)、(4.58±0.76)mmol/L,찬후2소시혈당(PPG)분별위(15.91±2.34)、(13.79±3.29)、(6.16±0.83)mmol/L,삼조간혈청hs-CRP비교,P균<0.01;A、B조여C조HbA1c、FPG、PPG비교,P균<0.01。 A、B、C조TC분별위(5.84±0.56)、(5.47±0.34)、(3.31±0.25)mmol/L,TG분별위(2.27±0.27)、(2.18±0.23)、(1.21±0.19)mmol/L,LDL-C분별위(4.46±0.91)、(4.34±0.67)、(2.07±0.31) mmol/L,HDL-C분별위(1.17±0.37)、(1.21±0.42)、(1.51±0.62)mmol/L,A、B조TC、TG、LDL-C、HDL-C여C조비교,P균<0.01。상관분석결과현시,혈청hs-CRP여HbA1c、FPG、PPG、TC、TG、LDL-C균정정상관( r분별위0.3685、0.4393、0.3847、0.3069、0.3431、0.4045,P균<0.01),여HDL-C정부상관(r=-0.2393,P<0.01)。결론 T2DM반대혈관병변환자혈청hs-CRP수평명현승고;hs-CRP가능삼여료T2DM혈관병변적병리과정。
Objective To investigate the level change of serum hypersensitive c-reactive protein ( hs-CRP) and its sig-nificance in type 2 diabetes mellitus (T2DM) patients with vascular lesions.Methods Selection of 45 patients with T2DM combined large vascular lesions (group A) and 45 cases of pure T2DM patients (group B) and 40 cases of healthy physical examination ( group C) , with transmission turbidimetric method to detect serum hs-CRP, using automatic biochemistry ana-lyzer determination of blood lipid , micro column method was used to measure blood sugar .The relationship among the ser-um hs-CRP and blood glucose , blood lipid in group A was performed by Pearson correlation analysis .Results The serum hs-CRP in group A, B, C was(4.12 ±2.15), (2.16 ±0.92), (0.62 ±0.34) ng/mL, glycosylated hemoglobin (HbA1c) was 11.09%±1.67%, 9.27%±1.21%, 4.17%±0.41%, fasting blood glucose (FPG) was (11.86 ± 3.91), (10.97 ±3.36), (4.58 ±0.76)mmol/L, postprandial 2 hours blood glucose (PPG) was (15.91 ±2.34), (13.79 ±3.29), (6.16 ±0.83)mmol/L.Comparison of serum hs-CRP among the three groups, P<0.01.Group A and group B compared with group C of HbA1c, FPG, PPG, P<0.01.The level of TC in group A, B, C was(5.84 ±0.56), (5.47 ±0.34), (3.31 ±0.25)mmol/L, TG was (2.27 ±0.27), (2.18 ±0.23), (1.21 ±0.19)mmol/L, LDL-C was (4.46 ±0.91), (4.34 ±0.67), (2.07 ±0.31)mmol/L, HDL-C was(1.17 ±0.37), (1.21 ±0.42), (1.51 ±0.62) mmol/L, the level of TC, TG, LDL-C, HDL-C in group A, B compared with group C, P<0.01.Correlation analysis re-sults showed that serum hs-CRP and HbA1c , FPG, PPG, TC, TG, LDL-C were positively correlated ( r were 0.368 5, 0.439 3, 0.384 7, 0.306 9, 0.343 1, 0.404 5, P<0.01), and negatively correlated with HDL-C (r=0.239 3, P<0.01).Conclusion The level of serum hs-CRP increase significantly in T2DM patients with vascular lesions .The hs-CRP may participate in the T2DM of the pathological process of vascular lesions .