CAJ | 학술논문

目的：观察剖宫产术后应用喷他佐辛静脉自控镇痛的效果。方法选择2012年1月—2013年1月行剖宫产术的产妇180例，随机分为喷他佐辛组、芬太尼组和对照组，每组60例。喷他佐辛组给予喷他佐辛+阿扎司琼，芬太尼组给予芬太尼+阿扎司琼，对照组不给予镇痛。采用视觉模拟评分法( VAS)评估产妇术后6、12、24、48 h的疼痛程度。于术前、术后24和48 h采用放射免疫分析法测定产妇血清泌乳素。观察3组不良反应发生情况。结果术后6、12、24、48 h喷他佐辛组与芬太尼组VAS评分低于对照组(P<0．01)。术后24、48 h喷他佐辛组与芬太尼组血清泌乳素浓度显著高于对照组(P<0．01)。喷他佐辛组产妇恶心、呕吐发生率低于芬太尼组(P<0．05)。结论剖宫产术后应用喷他佐辛静脉自控镇痛效果明显，可提高血清泌乳素的浓度，且不良反应较轻。
목적：관찰부궁산술후응용분타좌신정맥자공진통적효과。방법선택2012년1월—2013년1월행부궁산술적산부180례，수궤분위분타좌신조、분태니조화대조조，매조60례。분타좌신조급여분타좌신+아찰사경，분태니조급여분태니+아찰사경，대조조불급여진통。채용시각모의평분법( VAS)평고산부술후6、12、24、48 h적동통정도。우술전、술후24화48 h채용방사면역분석법측정산부혈청비유소。관찰3조불량반응발생정황。결과술후6、12、24、48 h분타좌신조여분태니조VAS평분저우대조조(P<0．01)。술후24、48 h분타좌신조여분태니조혈청비유소농도현저고우대조조(P<0．01)。분타좌신조산부악심、구토발생솔저우분태니조(P<0．05)。결론부궁산술후응용분타좌신정맥자공진통효과명현，가제고혈청비유소적농도，차불량반응교경。
Objective To observe the curative effect of patient-controlled intravenous analgesia with Pentazocine after cesarean section. Methods A total of 180 delivery women undergoing cesarean section during January 2012 and January 2013 were randomly divided into Pentazocine group (n=60), Fentanyl group (n=60) and control group (n=60) . Pentazocine group was given Pentazocine and Azasetron, and Fentanyl group was given Fentanyl and Azasetron, while control group was not given analgesia treatment. Visual analogue scales ( VAS) was used to evaluate the analgesia degree of delivery women on 6th h, 12th h, 24 th h and 48th h after cesarean section. The serum prolactin levels were detec-ted using radio immunoassay before the operation and on 24th h and 48th h after the operation. Adverse reactions were ob-served in the three groups. Results The VAS scores on 6th h, 12th h, 24 th h and 48th h after cesarean section in Pentazo-cine and Fentanyl groups were significantly lower than those in control group (P<0. 01). The prolactin concentrations on 24 th h and 48 th h after the operation in Pentazocine and Fentanyl groups were significantly higher than those in control group (P<0. 01). The incidence rates of nausea and emesis in Pentazocine group were significant lower than those in Fentanyl group ( P<0. 05 ) . Conclusion The patient-controlled intravenous analgesia with Pentazocine after cesarean section is effective, and it may significantly increase serum prolactin concentration with mild adverse reactions.