中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
3期
49-52
,共4页
解脲脲原体%支气管肺发育不良%感染%早产儿%相关性
解脲脲原體%支氣管肺髮育不良%感染%早產兒%相關性
해뇨뇨원체%지기관폐발육불량%감염%조산인%상관성
Ureaplasma urealyticum%Bronchopulmonary dysplasia%Infection%Premature infant%Correlation
目的：探讨解脲脲原体(UU)感染与早产儿支气管肺发育不良(BPD)的相关性,旨在为降低早产儿感染率提供临床依据。方法选择2012年8月~2014年7月浙江省义乌市妇幼保健院收治的胎龄<35周的早产儿148例作为研究对象。收集脐带血并采用荧光定量PCR技术和放射免疫技术测定早产儿的UU感染情况,并根据结果分为UU阳性组和UU阴性组,统计分析两组早产儿及产妇的基本临床特点,比较两组早产儿血培养、白细胞(WBC)、白细胞介素-8(IL-8)等相关血液指标及BPD发生率差异,分析UU和早产儿BPD的关系及其相关危险因素。结果148例早产儿中,UU阳性29例(19.59%),UU阴性119例(80.41%)；其中,UU阳性组的阴道分娩率及胎膜早破、绒毛膜羊膜炎发生率分别为86.21%、68.97%、10.34%,均显著高于UU阴性组(63.03%、36.13%、1.68%),两组间比较差异均有统计学意义(均P<0.05),UU阳性组产儿的体重[(1073.29±451.51)g],显著低于UU阴性组[(1725.15±518.18)g],差异有统计学意义(P<0.05)。 UU阳性组的IL-8水平[(11.96±2.85)μg/L]明显低于UU阴性组[(18.78±2.61)μg/L],差异有统计学意义(P<0.05),而两组血培养、WBC比较,差异无统计学意义(P >0.05)；另外,UU阳性组早产儿发生BPD者高达7例(24.14%),显著高于UU阴性组的5例(4.20%)。Logistic回归分析也显示,BPD的危险因素主要有阴道分娩、胎膜早破、绒毛膜羊膜炎和IL-8(OR=1.817、3.287、2.653、4.087,均P<0.05)。结论 UU感染与BPD密切相关,是早产儿BPD产生的重要原因之一,临床可根据产儿的感染情况及相关危险因素给予适当的干预措施,以有效降低产儿的感染率。
目的：探討解脲脲原體(UU)感染與早產兒支氣管肺髮育不良(BPD)的相關性,旨在為降低早產兒感染率提供臨床依據。方法選擇2012年8月~2014年7月浙江省義烏市婦幼保健院收治的胎齡<35週的早產兒148例作為研究對象。收集臍帶血併採用熒光定量PCR技術和放射免疫技術測定早產兒的UU感染情況,併根據結果分為UU暘性組和UU陰性組,統計分析兩組早產兒及產婦的基本臨床特點,比較兩組早產兒血培養、白細胞(WBC)、白細胞介素-8(IL-8)等相關血液指標及BPD髮生率差異,分析UU和早產兒BPD的關繫及其相關危險因素。結果148例早產兒中,UU暘性29例(19.59%),UU陰性119例(80.41%)；其中,UU暘性組的陰道分娩率及胎膜早破、絨毛膜羊膜炎髮生率分彆為86.21%、68.97%、10.34%,均顯著高于UU陰性組(63.03%、36.13%、1.68%),兩組間比較差異均有統計學意義(均P<0.05),UU暘性組產兒的體重[(1073.29±451.51)g],顯著低于UU陰性組[(1725.15±518.18)g],差異有統計學意義(P<0.05)。 UU暘性組的IL-8水平[(11.96±2.85)μg/L]明顯低于UU陰性組[(18.78±2.61)μg/L],差異有統計學意義(P<0.05),而兩組血培養、WBC比較,差異無統計學意義(P >0.05)；另外,UU暘性組早產兒髮生BPD者高達7例(24.14%),顯著高于UU陰性組的5例(4.20%)。Logistic迴歸分析也顯示,BPD的危險因素主要有陰道分娩、胎膜早破、絨毛膜羊膜炎和IL-8(OR=1.817、3.287、2.653、4.087,均P<0.05)。結論 UU感染與BPD密切相關,是早產兒BPD產生的重要原因之一,臨床可根據產兒的感染情況及相關危險因素給予適噹的榦預措施,以有效降低產兒的感染率。
목적：탐토해뇨뇨원체(UU)감염여조산인지기관폐발육불량(BPD)적상관성,지재위강저조산인감염솔제공림상의거。방법선택2012년8월~2014년7월절강성의오시부유보건원수치적태령<35주적조산인148례작위연구대상。수집제대혈병채용형광정량PCR기술화방사면역기술측정조산인적UU감염정황,병근거결과분위UU양성조화UU음성조,통계분석량조조산인급산부적기본림상특점,비교량조조산인혈배양、백세포(WBC)、백세포개소-8(IL-8)등상관혈액지표급BPD발생솔차이,분석UU화조산인BPD적관계급기상관위험인소。결과148례조산인중,UU양성29례(19.59%),UU음성119례(80.41%)；기중,UU양성조적음도분면솔급태막조파、융모막양막염발생솔분별위86.21%、68.97%、10.34%,균현저고우UU음성조(63.03%、36.13%、1.68%),량조간비교차이균유통계학의의(균P<0.05),UU양성조산인적체중[(1073.29±451.51)g],현저저우UU음성조[(1725.15±518.18)g],차이유통계학의의(P<0.05)。 UU양성조적IL-8수평[(11.96±2.85)μg/L]명현저우UU음성조[(18.78±2.61)μg/L],차이유통계학의의(P<0.05),이량조혈배양、WBC비교,차이무통계학의의(P >0.05)；령외,UU양성조조산인발생BPD자고체7례(24.14%),현저고우UU음성조적5례(4.20%)。Logistic회귀분석야현시,BPD적위험인소주요유음도분면、태막조파、융모막양막염화IL-8(OR=1.817、3.287、2.653、4.087,균P<0.05)。결론 UU감염여BPD밀절상관,시조산인BPD산생적중요원인지일,림상가근거산인적감염정황급상관위험인소급여괄당적간예조시,이유효강저산인적감염솔。
Objective To explore the correlation of preterm infection of ureaplasma urealyticum with bronchopulmonary dysplasia for the purpose of reducing the infection rate of preterm infants to provide clinical basis. Methods 148 cases of premature whose gestational age<35 weeks from August 2013 to July 2014 in Maternal and Child Health Hospital of Yiwu City were selected as the research subjects. The umbilical cord blood was collected and used the fluorescence quantitative PCR technique and radioimmunoassay to determinate the infection of ureaplasma urealyticum (UU). Ac-cording to the result, they were divided into the UU positive group and the UU negative group. The basic and clinical characteristics of two groups of preterm infant and maternal were statistical analyzed; the blood related indexes such as blood culture, WBC, IL-8 and the incidence of BPD in the preterm infants of the two groups were compared; the rela-tionship between UU and BPD in premature infants and its relative risk factors were analyzed. Results In 148 cases of preterm infants, 29 cases patients were UU positive (19.59%), 119 cases patients were UU negative (80.41%). Among them, the constitute of vaginal delivery, fetal membranes early broken and chorioamnionitis of UU positive group were 86.21%, 68.97%, 10.34% respectively, which were higher than those in the UU negative group (63.03%, 36.13%, 1.68%), the differences were statistically significant (all P<0.05), but the baby weight [(1073.29±451.51) g] was signif-icantly lower than that in the UU negative group [(1725.15±518.18) g], the difference was statistically significant (P<0.05). The IL-8 level of the UU positive group [(11.96±2.85) μg/L] was significantly lower than that in the UU negative group [(18.78±2.61) μg/L], the difference was statistically significant (P<0.05);while the blood culture, WBC of two positive group was up to 7 cases (24.14%), significantly higher than that 5 cases (4.20%) in the UU negative group. Lo-gistic regression analysis also showed that the vaginal delivery, premature rupture of membranes, chorioamnionitis and IL-8 were mainly risk factors of BPD (OR=1.817, 3.287, 2.653, 4.087, all P < 0.05). Conclusion Ureaplasma ure-alyticum infection is closely related with bronchopulmonary dysplasia, which is one of the important causes of prema-ture BPD production. According to the situation of perinatal infection and relate risk factors, clinic can give appropriate intervention measures to reduce the rate of perinatal infection.
