CAJ | 학술논문

“组分中药”组方来源于临床有效方剂，原料制备类似于天然药物，组方形式类似于固定剂量的复方制剂。目前，“组分中药”适应症多定位于慢性、难治、复杂性疾病，药效学目标多为疾病、症状或病理环节，可采用体内和体外实验方式，量效关系多呈非线性关系，涉及剂量-药效-病证三要素，综合评价方法尚处于探索阶段。在安全性评价方面，一般药理学研究较少，对毒性物质基础和量毒关系还需深入研究。组方合理性评价方面，包括组分辨识和组分配比优化，研究方法众多，但尚需在理论上加以提高，加强其系统性。药理机制研究方面结合了系统生物学、网络药理学等新理念、新技术，主要集中在多组分、多靶点、多途径、多药效的阐释上，今后应加强组分-靶点间的对应关系及网络关系研究，解释各组分对整体贡献的内在机理。
“조분중약”조방래원우림상유효방제，원료제비유사우천연약물，조방형식유사우고정제량적복방제제。목전，“조분중약”괄응증다정위우만성、난치、복잡성질병，약효학목표다위질병、증상혹병리배절，가채용체내화체외실험방식，량효관계다정비선성관계，섭급제량-약효-병증삼요소，종합평개방법상처우탐색계단。재안전성평개방면，일반약이학연구교소，대독성물질기출화량독관계환수심입연구。조방합이성평개방면，포괄조분변식화조분배비우화，연구방법음다，단상수재이론상가이제고，가강기계통성。약리궤제연구방면결합료계통생물학、망락약이학등신이념、신기술，주요집중재다조분、다파점、다도경、다약효적천석상，금후응가강조분-파점간적대응관계급망락관계연구，해석각조분대정체공헌적내재궤리。
“Multi-component Chinese medicine” was derived from effective clinical prescriptions, which is similar to natural medicines, and its form is similar to the fixed-dose compounds. The adaptable indications mainly cast chronic, intractable, and complex diseases. Its research targets of pharmacology mostly are diseases, symptoms or pathological process. Vivo and vitro experiments can be used in its researches. Its dose-effect relationship mostly shows non-linear relationship, and three elements (dose, efficacy and syndrome) are involved. However, the comprehensive evaluation method is still in the exploratory stag. In the safety evaluation, there were few general pharmacological researches, and the basis of toxicity and the relationship between amount and toxicity need further study. In combined optimization aspect, including identification of components and component ratio optimization, many methods have been developed, but it still needs to be developed in theory and systemic integration. Pharmacological mechanism researches focus on the multi-component, multi-target, multi-pathway, and multi-pharmacodynamics aspects, combined with new ideas and new technologies, such as systems biology, network pharmacology, etc. But as multi-component medicine, it should also be studied about the correspondence and network relationships of component and target, with a purpose to explain the contribution of each component in overall mechanism.