CAJ | 학술논문

目的：探讨血清炎症因子白细胞介素18( IL-18)、白细胞介素1β( IL-1β)与非酒精性脂肪性肝病( NAFLD)的关系。方法选取NAFLD患者作为NAFLD组( n=46)、正常对照者作为对照组(n=45),对被选人群进行问卷调查、体格测量、人体成分分析及肝脏超声检查。收集其体检报告。ELISA法检测血清IL-18、IL-1β。结果 NAFLD组体质指数( BMI)、内脏脂肪面积、体脂百分比、腰臀百分比、白细胞计数、中性粒细胞绝对数、淋巴细胞计数、空腹血糖、三酰甘油( TG)、极低密度脂蛋白、谷丙转氨酶、血尿酸及IL-18、IL-1β均明显高于对照组,差异有统计学意义( P<0．05)。同时,相关分析显示血清IL-18及IL-1β水平与BMI、TG均有相关性。结论在NAFLD患者血清中炎症因子IL-18、IL-1β均明显升高,IL-18、IL-1β参与的慢性炎症反应可能是NAFLD的病因之一。
목적：탐토혈청염증인자백세포개소18( IL-18)、백세포개소1β( IL-1β)여비주정성지방성간병( NAFLD)적관계。방법선취NAFLD환자작위NAFLD조( n=46)、정상대조자작위대조조(n=45),대피선인군진행문권조사、체격측량、인체성분분석급간장초성검사。수집기체검보고。ELISA법검측혈청IL-18、IL-1β。결과 NAFLD조체질지수( BMI)、내장지방면적、체지백분비、요둔백분비、백세포계수、중성립세포절대수、림파세포계수、공복혈당、삼선감유( TG)、겁저밀도지단백、곡병전안매、혈뇨산급IL-18、IL-1β균명현고우대조조,차이유통계학의의( P<0．05)。동시,상관분석현시혈청IL-18급IL-1β수평여BMI、TG균유상관성。결론재NAFLD환자혈청중염증인자IL-18、IL-1β균명현승고,IL-18、IL-1β삼여적만성염증반응가능시NAFLD적병인지일。
Objective To investigate the relationship of the serum levels of interleukin-18(IL-18),interleukin-1β( IL-1β) with pathogenesis of nonalcoholic fatty liver disease( NAFLD) . Methods 46 cases of NAFLD patients, 45 cases of normal controls were selected, questionnaire survey, physical measurement, body composition and liver ultrasound were conducted for selected population. Collect the physical examination report, serum levels of IL-18 and IL-1β were examined by ELISA. Results The body mass index (BMI),visceral fat area,percent body fat, waist-hip ratio,white blood cell, absolute neutrophil count, absolute lymphocyte count, fasting plasma glucose, tri-glycerides( TG) ,very low density lipoprotein,alanine transaminase and blood uric acid,serum levels of IL-18 and IL-1β were significantly higher in NAFLD group than in control group(P<0. 05),with statistical significance. The correlative analysis showed that the serum levels of IL-18 and IL-1β were correlated with body mass index and tri-glycerides. Conclusion Serum levels of IL-18 and IL-1β in NAFLD group are higher than those in control group, IL-18 and IL-1β participating in chronic inflammation may be one of the causes of NAFLD.