CAJ | 학술논문

目的：对血塞通软胶囊活血化瘀的作用进行药效学评价。方法：采用血塞通软胶囊灌胃给药7d，颈动脉采血观察血塞通软胶囊对正常大鼠血小板聚集及凝血四项指标的影响；采用冰水浴联合皮下注射盐酸肾上腺素的方法制备血瘀大鼠模型，观察血塞通软胶囊对血瘀大鼠血小板聚集及凝血四项指标的影响。结果：血塞通软胶囊（56、28mg／kg）能显著抑制正常大鼠及血瘀大鼠血小板聚集（P ＜0.05），同时血塞通软胶囊（56mg／kg）能明显延长血瘀大鼠 TT 和 APTT，减少 FIB （P ＜0.05）。但血塞通软胶囊（56、28、14mg／kg）对正常大鼠凝血四项指标均无明显的影响（P ＞0.05）。结论：血塞通软胶囊具活血化瘀作用，其活血化瘀作用可能对视网膜中央静脉栓塞有治疗作用。
목적：대혈새통연효낭활혈화어적작용진행약효학평개。방법：채용혈새통연효낭관위급약7d，경동맥채혈관찰혈새통연효낭대정상대서혈소판취집급응혈사항지표적영향；채용빙수욕연합피하주사염산신상선소적방법제비혈어대서모형，관찰혈새통연효낭대혈어대서혈소판취집급응혈사항지표적영향。결과：혈새통연효낭（56、28mg／kg）능현저억제정상대서급혈어대서혈소판취집（P ＜0.05），동시혈새통연효낭（56mg／kg）능명현연장혈어대서 TT 화 APTT，감소 FIB （P ＜0.05）。단혈새통연효낭（56、28、14mg／kg）대정상대서응혈사항지표균무명현적영향（P ＞0.05）。결론：혈새통연효낭구활혈화어작용，기활혈화어작용가능대시망막중앙정맥전새유치료작용。
Objective To observe the effect of Xuesaitong soft capsule (XST)on platelet aggregation and four blood coagulation parmeters in normal and blood stasis rats,and provide the experimental basis for the treatment of central retinal vein occlusion.Meth-ods Xuesaitong soft capsule i.g.in rats for 7days.Carotid artery blood in normal rats was used to assay platelet aggregation and four blood coagulation parmeters.The blood stasis rat model were established by epinephrine hydrochloride subcu -taneous injection and ice water immertion.Platelet aggregation and four blood coagulation parmeters in blood stasis rats were observed.Results XST (56、28mg/kg)could obviously prevent platelet aggregation in normal and blood stasis rats (P <0.05).XST (56mg/kg)could signifi-cantly increase the time of TT and APTT (P <0.05),and reduce the content of FIB in blood stasis rats (P <0.05).But XST (56、28、14mg/kg)had no effect on four blood coagulation parmeters in normal rats (P >0.05).Conclusion XST can improve the plate-let aggregation and four blood coagulation parmeters in the hypercoagulable state,and indicate that XST has the treatment effect of cen-tral retinal vein occlusion.