CAJ | 학술논문

目的：探讨Castleman病( Castleman′s disease, CD)的临床病理学特征、诊断及鉴别诊断。方法对10例CD进行临床资料分析、病理形态学观察及免疫组化检测,并复习相关文献。结果10例CD中,8例为单中心型,2例为多中心型；6例为透明血管型,1例为浆细胞型,3例为混合型。免疫表型：所有病例中BCL-6和CD10均阴性,Ki-67增殖指数均≤30%。10例患者中4例有完整的随访资料,其中1例为混合型,3例为透明血管型,手术切除后均痊愈,未复发。结论 CD是一种少见的、病因不明的淋巴组织增生性疾病,术前临床诊断有一定困难。免疫表型特征是否为CD患者免疫功能异常的反映,及其在CD发病机制上起何种作用,仍需进一步深入分析。
목적：탐토Castleman병( Castleman′s disease, CD)적림상병이학특정、진단급감별진단。방법대10례CD진행림상자료분석、병리형태학관찰급면역조화검측,병복습상관문헌。결과10례CD중,8례위단중심형,2례위다중심형；6례위투명혈관형,1례위장세포형,3례위혼합형。면역표형：소유병례중BCL-6화CD10균음성,Ki-67증식지수균≤30%。10례환자중4례유완정적수방자료,기중1례위혼합형,3례위투명혈관형,수술절제후균전유,미복발。결론 CD시일충소견적、병인불명적림파조직증생성질병,술전림상진단유일정곤난。면역표형특정시부위CD환자면역공능이상적반영,급기재CD발병궤제상기하충작용,잉수진일보심입분석。
Purpose To describe clinicopathological features, diagnosis and differential diagnosis of Castleman′s disease. Methods Retrospective analyses of the clinical data, clinicopathology and immunohistochemistry were conducted in ten cases of Castleman dis-ease and reviewed of literature. Results There were 8 cases of unicenrtic Castleman′s disease and 2 cases of multicentric Castleman′s disease. Pathologically, there were 6 cases of hayline vascular types, one case of plasmatcyic type and 3 cases of mixed type in all Castleman′s disease. Immunohistochemically, all cases were negative for BCL-6 and CD10, and Ki-67 expression was less than or e-qual to 30%. There were 4 cases with complete follow-up data, including one case of intermediate type, 3 cases of hyaline vascular type which were healed by surgical resection without recurrence. Conclusions Castleman′s disease is a rare and lymphoproliferative disorders with unknown cause, it is not easy to diagnose before the operation. Whether immunohistochemical features reflect abnormal immune function or play unknown role in the pathogenesis of Castleman′s disease is also demanded further study.