CAJ | 학술논문

目的：探讨p63在结节性淋巴细胞为主型霍奇金淋巴瘤( nodular lymphocyte predominant Hodgkin lymphoma, NLPHL)和经典型霍奇金淋巴瘤( classical Hodgkin lymphoma, CHL)中表达及临床意义。方法采用免疫组化EliVision法检测15例NL-PHL和54例CHL中CD45、CD30、p63、PAX5、CD20、CD15、Oct-2、BOB1、MUM1、EMA、EBV-LMP1、Ki-67等表达,用原位杂交法检测12例CHL中EBER表达。结果 NLPHL中p63阳性率(53．3%,8/15)明显高于CHL组(0,0/54)(P<0．05)。结论p63蛋白表达常见于NLPHL,有助于NLPHL和CHL的鉴别诊断。
목적：탐토p63재결절성림파세포위주형곽기금림파류( nodular lymphocyte predominant Hodgkin lymphoma, NLPHL)화경전형곽기금림파류( classical Hodgkin lymphoma, CHL)중표체급림상의의。방법채용면역조화EliVision법검측15례NL-PHL화54례CHL중CD45、CD30、p63、PAX5、CD20、CD15、Oct-2、BOB1、MUM1、EMA、EBV-LMP1、Ki-67등표체,용원위잡교법검측12례CHL중EBER표체。결과 NLPHL중p63양성솔(53．3%,8/15)명현고우CHL조(0,0/54)(P<0．05)。결론p63단백표체상견우NLPHL,유조우NLPHL화CHL적감별진단。
Purpose To investigate the expression and clinical significance of p63 in nodular lymphocyte predominant Hodgkin lym-phoma (NLPHL) and classical Hodgkin lymphoma (CHL). Methods 15 cases of NLPHL and 54 cases of CHL were stained for CD45, CD30, p63, PAX5, CD20, CD15, Oct-2, BOB1, MUM1, EMA, EBV-LMP1 and Ki-67 by immunohistochemical methods of EliVision. EBER were detected by in situ hybridization method in 12 cases of CHL. Results The expression of p63 in NLPHL (53. 3%, 8/15) was significantly higher than that in CHL (0, 0/54) (P<0. 05). Conclusions p63 protein is frequently expressed in NLPHL and helpful in the differential diagnosis between NLPHL and CHL.