临床与实验病理学杂志
臨床與實驗病理學雜誌
림상여실험병이학잡지
CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2015年
1期
48-51
,共4页
胃肿瘤%上皮细胞-间质转化%zeb-1%c-jun%免疫组织化学
胃腫瘤%上皮細胞-間質轉化%zeb-1%c-jun%免疫組織化學
위종류%상피세포-간질전화%zeb-1%c-jun%면역조직화학
gastric neoplasm%epithelial-mesenchymal transition%zeb-1%c-jun%immunohistochemistry
目的：探讨胃癌组织中zeb-1和c-jun蛋白的表达及对肿瘤发生、发展的影响。方法采用免疫组化PV两步法检测100例胃癌及癌旁组织中zeb-1、c-jun和E-cadherin的表达。结果胃癌组织中zeb-1、c-jun和E-cadherin的阳性率分别为81%、70%、35%；癌旁组织中zeb-1、c-jun和E-cadherin的阳性率分别为17%、25%、100%。 zeb-1和c-jun蛋白在胃癌组织中的表达均显著高于癌旁组织(P<0．05)。 zeb-1表达与肿瘤浸润深度、分化程度、淋巴结转移、TNM分期有关(P<0.05)；与患者年龄、性别、肿块大小无相关性。 c-jun表达与肿瘤分化程度有关(P<0．05),与其它临床病理特征无相关性。 zeb-1与E-cadherin在胃癌组织中表达呈负相关(P<0．05),zeb-1与c-jun在胃癌组织中表达呈正相关。 zeb-1与c-jun高表达者术后5年生存率明显低于低表达者。结论 zeb-1与c-jun高表达与胃癌的发生、发展密切相关,可作为判断胃癌预后的指标。
目的：探討胃癌組織中zeb-1和c-jun蛋白的錶達及對腫瘤髮生、髮展的影響。方法採用免疫組化PV兩步法檢測100例胃癌及癌徬組織中zeb-1、c-jun和E-cadherin的錶達。結果胃癌組織中zeb-1、c-jun和E-cadherin的暘性率分彆為81%、70%、35%；癌徬組織中zeb-1、c-jun和E-cadherin的暘性率分彆為17%、25%、100%。 zeb-1和c-jun蛋白在胃癌組織中的錶達均顯著高于癌徬組織(P<0．05)。 zeb-1錶達與腫瘤浸潤深度、分化程度、淋巴結轉移、TNM分期有關(P<0.05)；與患者年齡、性彆、腫塊大小無相關性。 c-jun錶達與腫瘤分化程度有關(P<0．05),與其它臨床病理特徵無相關性。 zeb-1與E-cadherin在胃癌組織中錶達呈負相關(P<0．05),zeb-1與c-jun在胃癌組織中錶達呈正相關。 zeb-1與c-jun高錶達者術後5年生存率明顯低于低錶達者。結論 zeb-1與c-jun高錶達與胃癌的髮生、髮展密切相關,可作為判斷胃癌預後的指標。
목적：탐토위암조직중zeb-1화c-jun단백적표체급대종류발생、발전적영향。방법채용면역조화PV량보법검측100례위암급암방조직중zeb-1、c-jun화E-cadherin적표체。결과위암조직중zeb-1、c-jun화E-cadherin적양성솔분별위81%、70%、35%；암방조직중zeb-1、c-jun화E-cadherin적양성솔분별위17%、25%、100%。 zeb-1화c-jun단백재위암조직중적표체균현저고우암방조직(P<0．05)。 zeb-1표체여종류침윤심도、분화정도、림파결전이、TNM분기유관(P<0.05)；여환자년령、성별、종괴대소무상관성。 c-jun표체여종류분화정도유관(P<0．05),여기타림상병리특정무상관성。 zeb-1여E-cadherin재위암조직중표체정부상관(P<0．05),zeb-1여c-jun재위암조직중표체정정상관。 zeb-1여c-jun고표체자술후5년생존솔명현저우저표체자。결론 zeb-1여c-jun고표체여위암적발생、발전밀절상관,가작위판단위암예후적지표。
Purpose To study the expression of zeb-1 and c-jun in gastric cancer and its influence of occurrence and development of tumor. Methods The expression zeb-1, c-jun and E-cadherin were assessed in 100 specimens of gastric cancer and their tissue adja-cent to cancer by immunohistochemistry. Results The positive rates of zeb-1,c-jun and E-cadherin expression in gastric cancer were 81%, 70%, 35%, and in tissue adjacent to cancer were 17%, 25%, 100%. The expression of zeb-1 and c-jun in gastric cancer were higher than those in their tissue adjacent to cancer (P<0. 05). zeb-1 expression was closely correlated with the degree of tumor differentiation, depth of invasion, lymph node metastasis and TNM stage (P<0. 05), which were not correlated with patient s age, sex and tumor size. c-jun expression was closely correlated with the degree of tumor differentiation (P<0. 05), which were not correlated with other pathological features. The expression of zeb-1 was negatively correlated with the expression of E-cadherin and was positively correlated with the expression of c-jun in gastric cancer. Patients with high expression of zeb-1 and c-jun had lower five-year survival rate than patients with negative expression. Conclusion zeb-1 and c-jun are closely correlated with occurrence and development of gastric cancer. They can be a index of judging prognosis of gastric cancer.
