CAJ | 학술논문

目的：探讨阿莫西林与阿莫西林-克拉维酸钾的不良反应。方法对收集的235例阿莫西林与146例阿莫西林-克拉维酸钾不良反应报告进行回顾性分析，前者纳入单用组，后者纳入复方组，比较两组患者一般资料、不良反应发生类型以及不良反应发生时间。结果两组患者性别、年龄分布、应用、体质量等临床资料比较，差异均无统计学意义（均P＞0.05）；单用组患者皮肤及附件、全身系统、呼吸系统、肝胆系统以及其他不良反应发生率明显高于复方组，单用组患者的胃肠反应、循环系统、中枢神经系统不良反应发生率明显低于复方组，差异均有统计学意义（均P＜0.05）；单用组患者3 d后不良反应发生率为13.6%，明显高于复方组的1.4%，差异有统计学意义（P＜0.05）。结论阿莫西林-克拉维酸钾相较于阿莫西林，不良反应发生时间较早、症状轻，不良反应集中在皮肤及附件、胃肠道、全身，但可增加循环系统、中枢神经系统不良反应发生风险，针对伴有以上系统合并症的患者，需谨慎应用。
목적：탐토아막서림여아막서림-극랍유산갑적불량반응。방법대수집적235례아막서림여146례아막서림-극랍유산갑불량반응보고진행회고성분석，전자납입단용조，후자납입복방조，비교량조환자일반자료、불량반응발생류형이급불량반응발생시간。결과량조환자성별、년령분포、응용、체질량등림상자료비교，차이균무통계학의의（균P＞0.05）；단용조환자피부급부건、전신계통、호흡계통、간담계통이급기타불량반응발생솔명현고우복방조，단용조환자적위장반응、순배계통、중추신경계통불량반응발생솔명현저우복방조，차이균유통계학의의（균P＜0.05）；단용조환자3 d후불량반응발생솔위13.6%，명현고우복방조적1.4%，차이유통계학의의（P＜0.05）。결론아막서림-극랍유산갑상교우아막서림，불량반응발생시간교조、증상경，불량반응집중재피부급부건、위장도、전신，단가증가순배계통、중추신경계통불량반응발생풍험，침대반유이상계통합병증적환자，수근신응용。
Objective To adverse reaction of amoxicilin and amoxicilin clavulanate potassium.Methods 235 cases with poor to colect 146 cases of amoxicilin and amoxicilin clavulanate potassium reaction reports were retrospectively analyzed,the former into the single group,the latter into compound group,compared two groups of patients with general information,adverse reaction and the type of adverse reaction time.Results Comparison of the clinical data of two groups in sex,age distribution,application direction,body quality,no significant difference(P>0.05); single group of patients with skin and accessories,general system,respiratory system,hepatobiliary system and other adverse reaction rate was significantly higher than that of compound group,with the single group of patients with gastrointestinal reaction,circulation system and central nervous system adverse reaction incidence was significantly lower than the compound group,the difference was statisticaly significant(P<0.05);single group of patients after 3 D, the incidence rate of adverse reaction was 13.6%,significantly higher than the group of compound 1.4%,the difference was statisticaly significant(P<0.05).Conclusion Amoxicilin and clavulanate potassium compared with amoxicilin, adverse reaction time is earlier,lighter adverse reaction symptoms,concentrated in the skin and appendages, gastrointestinal tract,systemic,but can increase the circulation system,the adverse reaction of central nervous system adverse reactions occurred in patients with more risk,system complications,should be used with caution.