中国药物经济学
中國藥物經濟學
중국약물경제학
CHINA JOURNAL OF PHARMACEUTICAL ECONOMICS
2015年
2期
173-175
,共3页
下呼吸道感染%鲍曼不动杆菌%分布%耐药性
下呼吸道感染%鮑曼不動桿菌%分佈%耐藥性
하호흡도감염%포만불동간균%분포%내약성
Lower respiratory tract infections%Acinetobacter Baumanni%Distribution%Drug resistance
目的:探讨212例下呼吸道鲍曼不动杆菌感染分布表现、耐药性特点及多重耐药菌的易感因素。方法2010年4月至2012年4月我院收治212例下呼吸道感染患者,对其分离出的212株鲍曼不动杆菌进行调查,分析其分布、耐药性及多重耐药性患者和非多重耐药性患者两者间的易感因素。结果212例下呼吸道感染患者分离出鲍曼不动杆菌212株,其中多重耐药80株,主要分布在重症监护病房(ICU),其次为呼吸内科、神经内科等。2010-2012年多重耐药的鲍曼不动杆菌构成比例分别36.2%、36.7%、39.2%;其特点是对多粘菌素B最为敏感,其次是替加环素;对含有β-内酰胺酶抑制剂复方制剂抗菌类药物均表现为明显的耐药性。结论鲍曼不动杆菌对多粘菌素B最为敏感,其次是替加环素,对碳青霉素烯类抗菌药物其耐药性呈现逐步上升的趋势;使用不同抗菌药物、并发心脑血管疾病以及病情变化成为多重耐药菌感染的主要易感因素。
目的:探討212例下呼吸道鮑曼不動桿菌感染分佈錶現、耐藥性特點及多重耐藥菌的易感因素。方法2010年4月至2012年4月我院收治212例下呼吸道感染患者,對其分離齣的212株鮑曼不動桿菌進行調查,分析其分佈、耐藥性及多重耐藥性患者和非多重耐藥性患者兩者間的易感因素。結果212例下呼吸道感染患者分離齣鮑曼不動桿菌212株,其中多重耐藥80株,主要分佈在重癥鑑護病房(ICU),其次為呼吸內科、神經內科等。2010-2012年多重耐藥的鮑曼不動桿菌構成比例分彆36.2%、36.7%、39.2%;其特點是對多粘菌素B最為敏感,其次是替加環素;對含有β-內酰胺酶抑製劑複方製劑抗菌類藥物均錶現為明顯的耐藥性。結論鮑曼不動桿菌對多粘菌素B最為敏感,其次是替加環素,對碳青黴素烯類抗菌藥物其耐藥性呈現逐步上升的趨勢;使用不同抗菌藥物、併髮心腦血管疾病以及病情變化成為多重耐藥菌感染的主要易感因素。
목적:탐토212례하호흡도포만불동간균감염분포표현、내약성특점급다중내약균적역감인소。방법2010년4월지2012년4월아원수치212례하호흡도감염환자,대기분리출적212주포만불동간균진행조사,분석기분포、내약성급다중내약성환자화비다중내약성환자량자간적역감인소。결과212례하호흡도감염환자분리출포만불동간균212주,기중다중내약80주,주요분포재중증감호병방(ICU),기차위호흡내과、신경내과등。2010-2012년다중내약적포만불동간균구성비례분별36.2%、36.7%、39.2%;기특점시대다점균소B최위민감,기차시체가배소;대함유β-내선알매억제제복방제제항균류약물균표현위명현적내약성。결론포만불동간균대다점균소B최위민감,기차시체가배소,대탄청매소희류항균약물기내약성정현축보상승적추세;사용불동항균약물、병발심뇌혈관질병이급병정변화성위다중내약균감염적주요역감인소。
Objective To shed light on the distribution, resistance characteristics and risk factors of multi-resistant bacteria, and to give clinical guidance for the use of antimicrobial drugs.Methods 2010 April to 2012 April in our hospital 212 cases of patients with lower respiratory tract infection,on 212 strains of Bauman Acinetobacter were investigated,analyzed the distribution,drug resistance and multi drug resistance patients and non multiple drug resistance patients between the susceptible factors.Results 212 cases of lower respiratory tract infection in patients with isolated Bauman Acinetobacter strain 212,among them 80 strains of multiple drug resistance,mainly distributed in the intensive care unit(ICU),folowed by respiratory department of Internal Medicine Department of internal medicine, nerve.2010-2012 years of multidrug resistant Acinetobacter proportion of Bauman were 36.2%,36.7%,39.2%; characteristics of polymyxin B was the most sensitive,folowed by tigecycline;containing beta lactamase inhibitor compound preparation of antibacterial drugs showed obvious resistance.Conclusion Bauman Acinetobacter to polymyxin B was the most sensitive,folowed by tigecycline on carbapenem antibacterial drug drug resistance has gradualy on the rise;the use of different antibiotics,and cardio cerebrovascular disease and ilness change become multi drug resistant bacteria infection major predisposing factors.