临床药物治疗杂志
臨床藥物治療雜誌
림상약물치료잡지
CLINICAL MEDICATION JOURNAL
2015年
1期
70-75
,共6页
张碧华%李寅%杨莉萍%胡欣
張碧華%李寅%楊莉萍%鬍訢
장벽화%리인%양리평%호흔
芪苈强心胶囊%地高辛%慢性心力衰竭%中西药相互作用%不良反应
芪藶彊心膠囊%地高辛%慢性心力衰竭%中西藥相互作用%不良反應
기력강심효낭%지고신%만성심력쇠갈%중서약상호작용%불량반응
Qili Qiangxin capsule%digoxin%chronic heart failure%interaction of tradition chinese medicine and western medicine%adverse drug reaction
目的：通过对北京医院（以下简称我院）芪苈强心胶囊的总体用药情况及其在治疗慢性心力衰竭方面与西药的联用情况进行回顾性分析，探讨中西药物联用对于治疗慢性心衰的临床价值和不良反应风险，促进药物的安全合理使用。方法：通过我院计算机系统，提取2011—2013年芪苈强心胶囊的用药人数、性别、年龄、用药科室、病种分布及与西药联用的数据，重点分析芪苈强心胶囊和西药强心药的相互作用，探讨中西药物之间是否有相互协同或是相互拮抗的作用关系。结果：芪苈强心胶囊从2011年开始在我院使用，用药人数、金额和频度在2012，2013年有较大增长。用药的大多为老年患者（80%在60岁以上），且以男性居多。用药数量最多为心血管内科，其次为中医科。临床主要用于治疗慢性心衰，并与多种西药联用，其中包括与地高辛等强心药的联用。结论：芪苈强心胶囊的使用主要以西医大夫为主，多用于慢性心衰的治疗，需要注重辨证用药；临床上发现将该药与地高辛联用会导致地高辛血药浓度升高，因此临床药师建议医生谨慎联用这两种药物，并在2013年杜绝了两药的联用。
目的：通過對北京醫院（以下簡稱我院）芪藶彊心膠囊的總體用藥情況及其在治療慢性心力衰竭方麵與西藥的聯用情況進行迴顧性分析，探討中西藥物聯用對于治療慢性心衰的臨床價值和不良反應風險，促進藥物的安全閤理使用。方法：通過我院計算機繫統，提取2011—2013年芪藶彊心膠囊的用藥人數、性彆、年齡、用藥科室、病種分佈及與西藥聯用的數據，重點分析芪藶彊心膠囊和西藥彊心藥的相互作用，探討中西藥物之間是否有相互協同或是相互拮抗的作用關繫。結果：芪藶彊心膠囊從2011年開始在我院使用，用藥人數、金額和頻度在2012，2013年有較大增長。用藥的大多為老年患者（80%在60歲以上），且以男性居多。用藥數量最多為心血管內科，其次為中醫科。臨床主要用于治療慢性心衰，併與多種西藥聯用，其中包括與地高辛等彊心藥的聯用。結論：芪藶彊心膠囊的使用主要以西醫大伕為主，多用于慢性心衰的治療，需要註重辨證用藥；臨床上髮現將該藥與地高辛聯用會導緻地高辛血藥濃度升高，因此臨床藥師建議醫生謹慎聯用這兩種藥物，併在2013年杜絕瞭兩藥的聯用。
목적：통과대북경의원（이하간칭아원）기력강심효낭적총체용약정황급기재치료만성심력쇠갈방면여서약적련용정황진행회고성분석，탐토중서약물련용대우치료만성심쇠적림상개치화불량반응풍험，촉진약물적안전합리사용。방법：통과아원계산궤계통，제취2011—2013년기력강심효낭적용약인수、성별、년령、용약과실、병충분포급여서약련용적수거，중점분석기력강심효낭화서약강심약적상호작용，탐토중서약물지간시부유상호협동혹시상호길항적작용관계。결과：기력강심효낭종2011년개시재아원사용，용약인수、금액화빈도재2012，2013년유교대증장。용약적대다위노년환자（80%재60세이상），차이남성거다。용약수량최다위심혈관내과，기차위중의과。림상주요용우치료만성심쇠，병여다충서약련용，기중포괄여지고신등강심약적련용。결론：기력강심효낭적사용주요이서의대부위주，다용우만성심쇠적치료，수요주중변증용약；림상상발현장해약여지고신련용회도치지고신혈약농도승고，인차림상약사건의의생근신련용저량충약물，병재2013년두절료량약적련용。
Objective:To analyze retrospectively the status of combination treatment of Qili Qiangxin capsule with the western medicine in the Chronic Heart Failure(CHF) patients in Beijing hospital, and the clinical value and adverse drug reaction (ADR) risk of the combination use were also discussed to promote the rational drug use.Methods: With the computer system, we extracted the data of patients number, sex, age, department, disease category and the combined western medicine related with Qili Qiangxin capsule from 2011 to 2013, focused on the interaction of Qili Qiangxin capsule and western medicine, and discussed the mutual coordination or mutual antagonism of Chinese and Western medicine. Results: Qili Qiangxin capsule was used in our hospital since 2011, which number, sum and frequency had much increased during 2012 and 2013. Most of the patients were elderly (80% were above 60 years old), and the majority were male. The department with the greatest drug assumption was cardiovascular department, the second one was Traditional Chinese Medicines(TCM) department. Qili Qiangxin capsule were administrated for CHF patients mostly, combined with many western medicine which included cardiotonic drugs such as digoxin.Conclusion: Qili Qiangxin capsule were prescribed to treat CHF mostly by western medicines doctors. The combination use of Qili Qiangxin capsule and digoxin could increase the blood concentration of digoxin, so clinical pharmacists suggested the combination to be used cautiously. And ifnally the combination use of the two drugs had been prevented since 2013.
