CAJ | 학술논문

目的：分析结直肠癌患者化疗后肝功能异常的特点和易感因素。方法：回顾性分析2013年6月—2014年5月中国医学科学院肿瘤医院内科住院治疗的结直肠癌患者化疗后肝功能异常的特点，对化疗后肝功能异常与临床参数进行相关因素分析。结果：580例患者共接受了3033周期的化疗，平均5.23周期/例，有170例在化疗过程中出现不同程度的肝功能异常，占29.3%。有140例为1度肝损伤，23例为2度损伤，6例为3度损伤，1例为4度损伤。相关因素分析显示肝功能异常与化疗总周期数、治疗类型及化疗药物相关（P<0.05）。结论：化疗所致肝功能异常的易感因素为化疗总周期数、治疗类型及化疗药物。化疗后肝功能异常的程度多为1度，化疗所致的肝损伤以肝细胞型为主。
목적：분석결직장암환자화료후간공능이상적특점화역감인소。방법：회고성분석2013년6월—2014년5월중국의학과학원종류의원내과주원치료적결직장암환자화료후간공능이상적특점，대화료후간공능이상여림상삼수진행상관인소분석。결과：580례환자공접수료3033주기적화료，평균5.23주기/례，유170례재화료과정중출현불동정도적간공능이상，점29.3%。유140례위1도간손상，23례위2도손상，6례위3도손상，1례위4도손상。상관인소분석현시간공능이상여화료총주기수、치료류형급화료약물상관（P<0.05）。결론：화료소치간공능이상적역감인소위화료총주기수、치료류형급화료약물。화료후간공능이상적정도다위1도，화료소치적간손상이간세포형위주。
Objective:To analyze the characteristics and risk factors of liver dysfunction after chemotherapy in patients with colorectal cancer.Methods: Characteristics of liver dysfunction in patients with colorectal cancer after chemotherapy who admitted to Cancer Institute & Hospital of Chinese Academy of Medical Sciences between June 2013 and May 2014 were retrospectively analyzed. Chi-square test was employed for univariate analysis on correlation between chemotherapy-induced liver dysfunction and clinical pathological parameters.Results: 580 patients received a total of 3 033 cycles of chemotherapy (5.23cycles/patient). There were 170 cases with chemotherapy induced different degree of liver dysfunction, the incidence rate was 29.3%.There were 140 cases in Grade 1 liver dysfunction, 23 cases in Grade 2, 6 cases in Grade 3 and 1 case in Grade 4. Conclusion: Predisposing factors for chemotherapy-induced liver dysfunction included the cycles of chemotherapy, the type of chemotherapy, and the chemotherapy regimens. Most common type of chemotherapy-induced liver dysfunction was hepatocellular necrosis and most of the disorder was of Grade1 abnormality.