CAJ | 학술논문

目的：探讨影响胃癌合并腹水患者生存的预后因素。方法回顾性分析2011年10月至2013年10月于本院住院治疗且随访资料完整的58例晚期胃癌合并腹水患者的病例资料，采用Kaplan?Meier法进行生存分析，Log?rank法进行单因素分析，Cox比例风险模型进行多因素分析。结果58例胃癌合并腹水患者的中位生存期为14?0月。单因素分析显示分化程度、浸润深度、肝脏转移情况、KPS评分和治疗方法与患者预后有关，而性别、年龄和腹水量则与预后无关。经Cox多因素回归分析，分化程度、浸润深度、肝脏转移情况、KPS评分及治疗方法是影响胃癌合并腹水患者预后的独立危险因素。结论分化程度、浸润深度、肝脏转移情况、KPS评分及治疗方法是影响胃癌合并腹水患者预后的强相关因素，可作为独立预后指标指导胃癌合并腹水患者的治疗。
목적：탐토영향위암합병복수환자생존적예후인소。방법회고성분석2011년10월지2013년10월우본원주원치료차수방자료완정적58례만기위암합병복수환자적병례자료，채용Kaplan?Meier법진행생존분석，Log?rank법진행단인소분석，Cox비례풍험모형진행다인소분석。결과58례위암합병복수환자적중위생존기위14?0월。단인소분석현시분화정도、침윤심도、간장전이정황、KPS평분화치료방법여환자예후유관，이성별、년령화복수량칙여예후무관。경Cox다인소회귀분석，분화정도、침윤심도、간장전이정황、KPS평분급치료방법시영향위암합병복수환자예후적독립위험인소。결론분화정도、침윤심도、간장전이정황、KPS평분급치료방법시영향위암합병복수환자예후적강상관인소，가작위독립예후지표지도위암합병복수환자적치료。
Objective To explore the independent prognosis factors of long?term survival for patients of gastric carcinoma with malignant ascites. Methods From December 2011 to October 2013, 58 gastric cancer patients with malignant ascites receiving treat?ment in Xijing Hospital were included in this study. Survival analysis was performed using Kaplan?Meier method. Univariate analysis of prognosis was made by Log?rank method. Multivariable analysis of prognosis was used by Cox proportional hazad regression model. Re?sults The median overall survival was 14?0 months. In univariate analysis, degree of differentiation, depth of invasion, liver metasta?sis, KPS score and therapeutic method correlated with the prognosis of the patients of gastric carcinoma with malignant ascites. Multiva?riate analysis revealed that degree of differentiation, depth of invasion, liver metastasis, KPS score and therapeutic method were inde?pendent risk factors of prognosis. Conclusion Degree of differentiation, depth of invasion, liver metastasis, KPS score and therapeutic method may serve as strong factors with gastric carcinoma. Dependent prognostic factors can guide the choice and practice of the therapy for gastric carcinoma with malignant ascites.