CAJ | 학술논문

目的：初步探讨5 mg/kg 阿米卡星在 PICU 患儿体内的药代动力学和血液动力学的关系。方法纳入符合条件的30例革兰阴性败血症患儿进行阿米卡星药物治疗研究,通过非房室模型计算每例患儿的阿米卡星的药代动力学。结果阿米卡星在革兰阴性败血症患儿体内平均药物分布为(0．36±0．07)L/kg,平均血液清除率为(3．88±0．97)mL/(min·kg)。肌酐清除率(CCR)与血清肌酸酐(SCr)相关性差异有统计学意义。结论对PICU患儿应用高剂量阿米卡星(≥25 mg/kg)需要考虑败血症对血液动力学的影响,要密切监测败血症患儿血药浓度变化。
목적：초보탐토5 mg/kg 아미잡성재 PICU 환인체내적약대동역학화혈액동역학적관계。방법납입부합조건적30례혁란음성패혈증환인진행아미잡성약물치료연구,통과비방실모형계산매례환인적아미잡성적약대동역학。결과아미잡성재혁란음성패혈증환인체내평균약물분포위(0．36±0．07)L/kg,평균혈액청제솔위(3．88±0．97)mL/(min·kg)。기항청제솔(CCR)여혈청기산항(SCr)상관성차이유통계학의의。결론대PICU환인응용고제량아미잡성(≥25 mg/kg)수요고필패혈증대혈액동역학적영향,요밀절감측패혈증환인혈약농도변화。
Objective To examine the relationship between pharmacokinetics and hemodynamic of 5 mg/kg amikacin in PICU sepsis children. Methods 30 patients who were treated with amikacin following Gram negative sep-sis were enrolled. The pharmacokinetic profile of amikacin by a non-compartmental model was calculated for each pa-tient. Results Mean volume of distribution was ( 0. 36 ± 0. 07 ) L/kg and mean serum amikacin clearance rate was (3. 88 ± 0. 97)mL/(min·kg). There was significant difference between the relationship of CCR and SCr. Conclusion Using high dose of amikacin(≥25 mg/kg) needs to consider hemodynamic response to sepsis and monitor the chan-ges of blood drug concentration.