CAJ | 학술논문

目的：为急性心肌梗死患者行急诊PCI前所需的负荷量阿司匹林联合氯吡格雷选择更优的给药途径提供依据。方法对入选的136例急性心肌梗死并行急诊PCI术的患者随机分成直接吞服组(直接组)和碾碎混合冲水顿服组(混合组),对比观察两组的服药耗时、胃肠道反应情况、严重心律失常发生率、患者满意度、血液检验指标等情况。结果直接吞服组服药耗时(68．28±7．73)s,明显短于混合组的(120．32±22．03)s(P<0．001)；直接组胃肠道反应情况较混合组明显减少(P<0．001),患者满意度明显升高(P<0．001)；两种给药方式血液指标比较差异无统计学意义(P>0．05)。结论直接吞服方式在保证疗效的同时,可提高护理工作效率,缩短急诊PCI术前准备时间,提高患者满意度。
목적：위급성심기경사환자행급진PCI전소수적부하량아사필림연합록필격뢰선택경우적급약도경제공의거。방법대입선적136례급성심기경사병행급진PCI술적환자수궤분성직접탄복조(직접조)화년쇄혼합충수돈복조(혼합조),대비관찰량조적복약모시、위장도반응정황、엄중심률실상발생솔、환자만의도、혈액검험지표등정황。결과직접탄복조복약모시(68．28±7．73)s,명현단우혼합조적(120．32±22．03)s(P<0．001)；직접조위장도반응정황교혼합조명현감소(P<0．001),환자만의도명현승고(P<0．001)；량충급약방식혈액지표비교차이무통계학의의(P>0．05)。결론직접탄복방식재보증료효적동시,가제고호리공작효솔,축단급진PCI술전준비시간,제고환자만의도。
Objective To choose the better way of taking loading dose of aspirin and clopidogrel for acute myocardial infarction( AMI ) before percutaneous coronary intervention ( PCI ) . Methods 136 patients were selected and randomly divided into two groups,the direct swallowing group and the crushing group. The time consuming of tak-ing medicine, gastrointestinal reactions, severe arrhythmias, patient′s satisfactions, blood tests and others of the two groups were compared. Results The time consuming of directly swallowing the medicine in the direct swallowing group was significantly shorter than that in crushing group:(68. 28 ± 7. 73) s vs. (120. 32 ± 22. 03) s,P<0. 001. The gastrointestinal reactions of direct swallowing group were significantly reduced and patient′s satisfactions were signifi-cantly improved than those in the crushing group ( P<0. 001 ) . The blood tests had no significant difference between the two groups(P>0. 05). Conclusion The way of directly swallow loading dose of aspirin and clopidogrel before e-mergency PCI has the same effects,less time consuming and fewer adverse reactions and higher satisfactions.