CAJ | 학술논문

目的：探讨益气复脉注射液治疗急性心功能不全的临床疗效。方法将2012年6月至2013年12月在我院急诊科治疗的85例急性心功能不全患者分为2组。对照组41例给予常规西医抗心衰治疗,给予利尿剂、血管紧张素转换酶抑制剂、β受体阻滞剂、洋地黄等。治疗组44例在西医治疗的基础上应用益气复脉注射液5．2 g加入5%葡萄糖250 mL,1次/d静滴。观察患者的症状、体征、心功能分级。两组患者治疗前及治疗14 d后测定脑钠肽( BNP)。超声心动图检查测定左房径( LAD),左室舒张末期容积( EDV),左室射血分数( LVEF),二尖瓣口舒张早期最大血流速度(E峰)、舒张晚期最大血流速度(A峰)。结果治疗组总有效率高于对照组,差异有统计学意义(P<0．05)；观察组患者疲乏、心悸、呼吸困难、心绞痛等症状缓解时间均短于对照组,差异有统计学意义(P<0．05)。治疗后,治疗组BNP浓度低于对照组射血分数及E/A高于对照组,左房内径及左室舒张末期容积低于对照组,差异均有统计学意义( P<0．05)。结论益气复脉注射液能明显改善心衰患者的临床症状及心脏功能,无明显不良反应,是治疗急性心功能不全较理想的药物。
목적：탐토익기복맥주사액치료급성심공능불전적림상료효。방법장2012년6월지2013년12월재아원급진과치료적85례급성심공능불전환자분위2조。대조조41례급여상규서의항심쇠치료,급여이뇨제、혈관긴장소전환매억제제、β수체조체제、양지황등。치료조44례재서의치료적기출상응용익기복맥주사액5．2 g가입5%포도당250 mL,1차/d정적。관찰환자적증상、체정、심공능분급。량조환자치료전급치료14 d후측정뇌납태( BNP)。초성심동도검사측정좌방경( LAD),좌실서장말기용적( EDV),좌실사혈분수( LVEF),이첨판구서장조기최대혈류속도(E봉)、서장만기최대혈류속도(A봉)。결과치료조총유효솔고우대조조,차이유통계학의의(P<0．05)；관찰조환자피핍、심계、호흡곤난、심교통등증상완해시간균단우대조조,차이유통계학의의(P<0．05)。치료후,치료조BNP농도저우대조조사혈분수급E/A고우대조조,좌방내경급좌실서장말기용적저우대조조,차이균유통계학의의( P<0．05)。결론익기복맥주사액능명현개선심쇠환자적림상증상급심장공능,무명현불량반응,시치료급성심공능불전교이상적약물。
Objective To investigate the clinical efficacy of Yi Qi Fu Mai injection in the treatment of acute heart failure. Methods Eighty-five patients with acute cardiac dysfunction from June 2012 to December 2013 in the e-mergency department of our hospital were randomly divided into control group (n=41) and treatment group (n=44). Control group was given conventional Western medicine treatment with diuretics,angiotensin-converting enzyme inhibi-tors,β-blockers,digitalis. Treatment group was treated with basic Western medicine and Yi Qi Fu Mai injection 5. 2 g added into 5%glucose injection 250 mL,once daily intravenously. Symptoms,signs,cardiac function were observed. The content of BNP before and after treatment were determined. LAD,EDV,LVEF,E peak,A peak were determined u-sing echocardiography. Results The total effective rate of treatment group was significantly higher than that of control group,symptoms of patients in observation group were fatigue,palpitation,dyspnea,angina,relief time,which were sig-nificantly shorter than those in control group. The difference was statistically significant(P<0. 05). After treatment, compared with control group,the concentration of BNP of treatment group was lower,the ejection fraction and E/A were higher,and the diameter of left atrial and left ventricular end diastolic volume were lower,there were significant differences(P<0. 05). Conclusion Yi Qi Fu Mai injection can significantly improve the clinical symptoms and cardi-ac function in patients with heart failure without significant adverse reactions,it is an ideal drug in the treatment of acute cardiac failure.