CAJ | 학술논문

目的：分析来氟米特联合银杏达莫治疗肾病综合征( NS)的疗效，改善NS患者高凝状态。方法将90例NS患者随机分为2组，每组45例。对照组给予来氟米特治疗，观察组给予来氟米特联合银杏达莫治疗，治疗1个月；治疗前、后检测血液高凝状态指标，观察治疗效果。结果治疗后两组肾功能指标较治疗前均有所改善，但组间比较差异无统计学意义(P>0．05)；治疗后观察组载脂蛋白B/载脂蛋白A-Ⅰ(ApoB/ApoA-Ⅰ)、血浆纤维蛋白原( FIB)、纤维蛋白原降解产物( FDP)低于治疗前及对照组，抗凝血酶Ⅲ( AT-Ⅲ)活性高于治疗前及对照组，差异有统计学意义(P<0．05)。结论对NS患者在来氟米特治疗基础上加用银杏达莫，可有效改善患者高凝状态。
목적：분석래불미특연합은행체막치료신병종합정( NS)적료효，개선NS환자고응상태。방법장90례NS환자수궤분위2조，매조45례。대조조급여래불미특치료，관찰조급여래불미특연합은행체막치료，치료1개월；치료전、후검측혈액고응상태지표，관찰치료효과。결과치료후량조신공능지표교치료전균유소개선，단조간비교차이무통계학의의(P>0．05)；치료후관찰조재지단백B/재지단백A-Ⅰ(ApoB/ApoA-Ⅰ)、혈장섬유단백원( FIB)、섬유단백원강해산물( FDP)저우치료전급대조조，항응혈매Ⅲ( AT-Ⅲ)활성고우치료전급대조조，차이유통계학의의(P<0．05)。결론대NS환자재래불미특치료기출상가용은행체막，가유효개선환자고응상태。
Objective To analyze the effect of leflunomide combined ginkgo leaf extract and dipyridamole in-jection in the treatment of patients with NS,so as to improve hypercoagulable state in patients with NS. Methods 90 patients with NS were randomly divided into two groups,45 cases in each group,control group was given leflunomide;while observation group received leflunomide combined with ginkgo leaf extract and dipyridamole injection. All the pa-tients were treated for 1 month;blood hypercoagulable state indicators and treatment effect of the two groups were ob-served. Results After treatment,renal function of the two groups had been improved,but the difference between the two groups was not significant(P>0. 05);apolipoprotein B/apolipoprotein A-Ⅰ(ApoB/ApoA-Ⅰ),plasma fibrinogen (FIB),fibrinogen degradation products(FDP)of observation group after treatment were lower than before treatment and control group,antithrombinⅢ( AT-Ⅲ) activity were higher than before treatment and control group,the differences were significant(P<0. 05). Conclusion For NS patients,based on the treatment of leflunomide,treated with ginkgo leaf extract and dipyridamole injection can effective improve hypercoagulable state.