CAJ | 학술논문

目的：探讨视黄醇结合蛋白（RBP）在不同临床类型肝损伤患者血清中的水平及临床意义。方法对370例肝病患者及50例健康对照者采用日立7600全自动生化分析仪分别测定 TBil、ALT、Alb 和 RBP，并进行统计分析。结果除脂肪肝组外，急性肝炎组、慢性肝炎组、药物性肝炎组、肝硬化组、自身免疫性肝炎组、肝癌组中 TBil、ALT 水平较对照组显著升高（P ＜0．05），Alb、RBP 水平较对照组显著降低（P ＜0．05）。RBP、Alb 降低具有一致性，在急性肝炎组、慢性肝炎组、药物性肝炎组、肝硬化组、肝癌组中的 RBP 异常率更高于 Alb 异常率（P ＜0．05）。结论RBP 检测可早期灵敏反映肝功能损伤情况，值得临床广泛使用。
목적：탐토시황순결합단백（RBP）재불동림상류형간손상환자혈청중적수평급림상의의。방법대370례간병환자급50례건강대조자채용일립7600전자동생화분석의분별측정 TBil、ALT、Alb 화 RBP，병진행통계분석。결과제지방간조외，급성간염조、만성간염조、약물성간염조、간경화조、자신면역성간염조、간암조중 TBil、ALT 수평교대조조현저승고（P ＜0．05），Alb、RBP 수평교대조조현저강저（P ＜0．05）。RBP、Alb 강저구유일치성，재급성간염조、만성간염조、약물성간염조、간경화조、간암조중적 RBP 이상솔경고우 Alb 이상솔（P ＜0．05）。결론RBP 검측가조기령민반영간공능손상정황，치득림상엄범사용。
Objective To investigate the levels and clinical significance of retinol binding protein (RBP)in patients with different clinical types of liver injury.Methods RBP,Total bilirubin (TB),alanine aminotransferase (ALT)and albumin (ALB)were detected and analyzed in 370 liver disease patients and 50 healthy person by Hitachi 7600 automatic biochemical analyzer.Results The TB,ALT levels were significantly higher,while the ALB and RBP levels in acute hepatitis,chronic hepatitis,drug-induced hepatitis,cirrhosis,autoimmune hepatitis,liver cancer group were significantly lower than those in control group (P <0.05),respectively.RBP declined consistently with ALB level.The abnormal rates of RBP were higher than those of ALB in acute hepatitis,chronic hepatitis,drug-induced hepatitis,cirrhosis and liver cancer groups (P <0.05),respectively.Conclusion RBP is a sensitive reflector of liver damage;it is helpful in the clinical application.