CAJ | 학술논문

目的：探讨不伴糖尿病的双相障碍（ BD）患者糖代谢水平。方法：对111例BD患者（ BD组）及41名正常对照者（ NC组）进行体质量指数（ BMI）、空腹血糖、胰岛素及糖化血红蛋白水平测定，计算胰岛素抵抗指数（IR）；分析影响BD患者糖代谢的因素。结果：BD组空腹胰岛素（6.5 fs 4.3 ug/ml，P﹤0.001）、IR（0.9 fs 0.7，P＝0.002）及IR发生率（44.1％ fs 22.4％，P＝0.027）显著高于NC组；在控制BMI因素后，BD组与NC组IR发生率差异无统计学意义。结论：不伴糖尿病的BD患者高胰岛素血症及IR发生率高，肥胖影响BD患者的糖代谢。
목적：탐토불반당뇨병적쌍상장애（ BD）환자당대사수평。방법：대111례BD환자（ BD조）급41명정상대조자（ NC조）진행체질량지수（ BMI）、공복혈당、이도소급당화혈홍단백수평측정，계산이도소저항지수（IR）；분석영향BD환자당대사적인소。결과：BD조공복이도소（6.5 fs 4.3 ug/ml，P﹤0.001）、IR（0.9 fs 0.7，P＝0.002）급IR발생솔（44.1％ fs 22.4％，P＝0.027）현저고우NC조；재공제BMI인소후，BD조여NC조IR발생솔차이무통계학의의。결론：불반당뇨병적BD환자고이도소혈증급IR발생솔고，비반영향BD환자적당대사。
Objective:To efaluate the glucose metabolic lefels in no comorbid diabetes patients with bi-polar disorder( BD) Method:The body mass index( BMI),the lefels of fasting plasma glucose,insulin and glycosylated hemoglobin were detected in 111 BD patients without diabetes( BD group)and 41 normal controls ( NC group). The insulin resistance index( IR)was calculated and the affecting factors of sugar metabolism in BD patients was analyzed. Results:In the BD group ,the lefels of fasting plasma insulin(6. 5 fs 4. 3 ug/ml, P﹤0. 001),IR(0. 9 fs 0. 7,P=0. 002)and incidence of IR(44. 1% fs 22. 4%,P=0. 027)were signifi-cantly higher than those in the NC group. The difference of IR incidence between the two groups was disap-peared after the factor of BMI was controlled. Conclusion:The incidences of hyperinsulinemia and IR in BD patients without diabetes are prefalent. Obesity affects sugar metabolism in BD patients.